Advances in Digestive Medicine, EarlyView.Abstract Pharyngeal high‐resolution manometry with impedance (P‐HRM‐I) is an established assessment method used to evaluate pharyngeal swallowing. It provides precise quantification of swallowing biomechanics that enable the detection of alterations in swallowing physiology.
Mistyka Schar +5 more
wiley +1 more source
Advanced Intelligent Discovery, EarlyView.This article implements a unified human digital twin framework that integrates cutting edge actuation, sensing, simulation, and bidirectional feedback capability. The approach includes integrating multimodal sensing, AI, and biomechanical simulation into one compact system.
Tajbeed Ahmed Chowdhury +4 more
wiley +1 more source
Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics
Advanced Intelligent Discovery, EarlyView.Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong +5 more
wiley +1 more source
When Biology Meets Medicine: A Perspective on Foundation Models
Advanced Intelligent Discovery, EarlyView.Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu +3 more
wiley +1 more source
High-Flow Nasal Cannula Outcomes in COVID-19-Associated Acute Hypoxemic Respiratory Failure: Illness Severity, Awake Prone Positioning, and Risk of Intubation in a Single-Center ICU Cohort. [PDF]
Medicina (Kaunas)Kılıçaslan MÖ +4 more
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang +9 more
wiley +1 more source
Apparent Survival Benefit of Postoperative Radioactive Iodine in Lymph Node-Positive Papillary Thyroid Carcinoma: A Negative-Control Analysis for Unmeasured Confounding. [PDF]
Cancer MedLiu T, Qiao J, Mao M, Guo Q, Yang F.
europepmc +1 more source
Fluorescent Hydrogel‐Based Strain Sensor With Machine Learning‐Augmented Performance
Advanced Intelligent Discovery, EarlyView.Fluorescent hydrogel strain sensor based on carbon quantum dots enabling optical readout of deformation through strain‐dependent emission changes, coupled with Random Forest analysis to capture nonlinear fluorescence‐concentration relationships and identify optimal sensing conditions. Hydrogels are ideal matrices for bio‐integrated wearable sensors due
Tailai Chen +4 more
wiley +1 more source
Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. [PDF]
Cardiovasc DiabetolLu A, Xu Q.
europepmc +1 more source
Advanced Intelligent Discovery, EarlyView.An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li +9 more
wiley +1 more source