Results 211 to 220 of about 283,448 (300)

Artificial Intelligence and Access to Justice at the ‘Shop Front’: The Potential and Limitations of Meeting Legal Need Through Technology

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT In Australia, governments fund Community Legal Centres (CLCs) as part of the legal assistance sector (LAS) to meet the ‘legal needs’ of people experiencing disadvantage who cannot afford private legal services. Persistent unmet demand for CLCs is well‐documented. As artificial intelligence (AI) is increasingly used in private legal practice to
Catherine Hastings   +2 more
wiley   +1 more source

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li   +11 more
wiley   +1 more source

From Atoms to Reactors: A Critical Review of a Decade of Machine Learning in Heterogeneous Catalysis (2017–2026)

open access: yesAngewandte Chemie, EarlyView.
Machine learning has digitalized heterogeneous catalysis from the top of the length scale downward: prediction at the atom and the material is now mature, yet the reactor and the process remain the open frontier. This critical review traces a decade of progress across the full catalytic value chain and asks where the next decade of impact must be won ...
Rafael Larraz, Avelino Corma
wiley   +2 more sources

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius   +3 more
wiley   +1 more source

Facile Synthesis of a Bis‐α‐aryl‐Substituted Pyclen‐Based Heptadentate Lanthanide Chelator for Ultra‐Robust and High‐Contrast MRI Agents and for Radiopharmaceuticals

open access: yesAngewandte Chemie, EarlyView.
A facile synthesis involving a three‐component Petasis reaction is reported to construct bis‐α‐aryl‐substituted PCTAs. The synthesis is the simplest among all previously reported work on α‐substituted PCTAs. One of the isomers results in a Gd complex that showed significantly improved robustness despite being heptadentate and q = 2. This complex should
Pak‐Lun Lam   +15 more
wiley   +2 more sources

Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid‐Positive Individuals

open access: yesAnnals of Neurology, EarlyView.
Objective Identification of cerebral amyloid angiopathy (CAA) before its hemorrhagic manifestations remains limited. We aimed to determine whether severe enlarged perivascular spaces in the centrum semiovale (EPVS‐CSO) identify a prehemorrhagic stage of sporadic CAA by predicting the first appearance of CAA‐related hemorrhagic lesions or incident ...
Baris Alten   +8 more
wiley   +1 more source

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