Results 31 to 40 of about 117,914 (228)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Leaf shape and size variability of Dryas octopetala in the Central Great Caucasus (the Kazbegi region, Georgia) based on traditional and geometric morphometrics [PDF]

Botanica Serbica
While soil pH is known to be a key driver of plant species composition, we still have a poor understanding of the quantification of the responses of leaf traits to different soil types, especially in highly sensitive alpine environments susceptible to
Jana Ekhvaia, Otar Abdaladze, Tamar Jolokhava, Arsen Bakhia   +3 more
doaj   +1 more source

Bir Expo Mirası Olarak Mimarlığın Kentler Üzerindeki Etkileri

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2023
Düzenlendikleri ilk günden itibaren EXPO’lar, kentlerin tarihlerinde önemli izler bırakan etkinlikler olmuşlardır. İlk sergi olan 1851 Londra Dünya Sergisinden başlayarak dört farklı kategoride düzenlenen EXPO’ların çoğu miras niteliğinde vurgularla ...
Bengi Polat, Senem Tezcan
doaj   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

An Audio-Based SLAM for Indoor Environments: A Robotic Mixed Reality Presentation

Sensors
In this paper, we present a novel approach referred to as the audio-based virtual landmark-based HoloSLAM. This innovative method leverages a single sound source and microphone arrays to estimate the voice-printed speaker’s direction.
Elfituri S. F. Lahemer, Ahmad Rad
doaj   +1 more source

Live Your Myth in Greece: Towards the Construction of a Heritage Identity

Heritage, 2019
Nowadays, top-rated tourist attractions in Greece are ancient archaeological places and islands with blue-and-white esthetics. The country’s projected impression is greatly based on these two distinguished representations, chosen for their distinctive ...
Myrto Stenou
doaj   +1 more source

Route schematization with landmarks

Journal of Spatial Information Science, 2020
Predominant navigation applications make use of a turn-by-turn instructions approach and are mostly supported by small screen devices. This combination does little to improve users' orientation or spatial knowledge acquisition.
Marcelo de Lima Galvão, Jakub Krukar, Martin Nöllenburg, Angela Schwering   +3 more
doaj   +1 more source