Results 41 to 50 of about 384,952 (256)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

From Excavation to Restitution of the Networks of Roman and Pre-roman Roads: The Footprints of the 2222 m and 2535 m Leagues in the Carnute, Senon and Parisii Territories (Gallia Lugdunensis/France)

Open Archaeology, 2017
The excavation of a section of the Old path from Orleans to Paris at Massy has shown a real archaeogeographical textbook case outlining the different phases of the transformation of a gallic sunken road in a gallo-roman road, whose route was used until ...
Bruant Jean
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Leaf shape and size variability of Dryas octopetala in the Central Great Caucasus (the Kazbegi region, Georgia) based on traditional and geometric morphometrics [PDF]

Botanica Serbica
While soil pH is known to be a key driver of plant species composition, we still have a poor understanding of the quantification of the responses of leaf traits to different soil types, especially in highly sensitive alpine environments susceptible to
Jana Ekhvaia, Otar Abdaladze, Tamar Jolokhava, Arsen Bakhia   +3 more
doaj   +1 more source

Bir Expo Mirası Olarak Mimarlığın Kentler Üzerindeki Etkileri

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2023
Düzenlendikleri ilk günden itibaren EXPO’lar, kentlerin tarihlerinde önemli izler bırakan etkinlikler olmuşlardır. İlk sergi olan 1851 Londra Dünya Sergisinden başlayarak dört farklı kategoride düzenlenen EXPO’ların çoğu miras niteliğinde vurgularla ...
Bengi Polat, Senem Tezcan
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Live Your Myth in Greece: Towards the Construction of a Heritage Identity

Heritage, 2019
Nowadays, top-rated tourist attractions in Greece are ancient archaeological places and islands with blue-and-white esthetics. The country’s projected impression is greatly based on these two distinguished representations, chosen for their distinctive ...
Myrto Stenou
doaj   +1 more source

Route schematization with landmarks

Journal of Spatial Information Science, 2020
Predominant navigation applications make use of a turn-by-turn instructions approach and are mostly supported by small screen devices. This combination does little to improve users' orientation or spatial knowledge acquisition.
Marcelo de Lima Galvão, Jakub Krukar, Martin Nöllenburg, Angela Schwering   +3 more
doaj   +1 more source

GIS METHODOLOGICAL APPROACH TO DEVELOPING AND FORMING A VISUAL IMAGE OF DOWNTOWN AMMAN

Architecture and Engineering, 2021
Introduction: Amman’s growth expansion was shaped by its topography (valleys and hills), which generated a special character and patterns of the urban form.
Al Fahmawee Emad Al Dein Hasan
doaj   +1 more source