Results 41 to 50 of about 269,796 (298)

Evaluation of buffer-radius modelling approaches used in forest conservation and planning [PDF]

, 2010
Spatial modelling approaches are increasingly being used to direct forest management and conservation planning at the landscape scale. A popular approach is the use of buffer-radius methods, which create buffers around distinct forest habitat patches to ...
Bailey, S., Brouwers, N.C., Newton, A.C., Watts, K.   +3 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Complementary network-based approaches for exploring genetic structure and functional connectivity in two vulnerable, endemic ground squirrels [PDF]

, 2017
The persistence of small populations is influenced by genetic structure and functional connectivity. We used two network-based approaches to understand the persistence of the northern Idaho ground squirrel (Urocitellus brunneus) and the southern Idaho ...
Adi Barocas, Adi Barocas, Agnès Pelletier, Daryl R. Trumbo, Denim M. Jochimsen, Diane Evans Mack, Jessica A. Castillo, Jessica Hoisington-Lopez, Lisette P. Waits, Mark A. Linnell, Melanie A. Murphy, Melanie A. Murphy, Rachel M. Pigg, Stephen F. Spear, Victoria H. Zero, Xavier Giroux-Bougard   +15 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Structural Connectivity of Asia’s Protected Areas Network: Identifying the Potential of Transboundary Conservation and Cost-Effective Zones

ISPRS International Journal of Geo-Information, 2022
Human activities can degrade landscape connectivity and disrupt ecological flows, jeopardising the functional integrity of processes. This study presents a quantitative assessment of Asia’s protected areas’ (PAs) structural connectivity using landscape ...
Melissa Penagos Gaviria, Żaneta Kaszta, Mohammad S. Farhadinia   +2 more
doaj   +1 more source

The Role of Landscape Connectivity in Planning and Implementing Conservation and Restoration Priorities. Issues in Ecology [PDF]

, 2012
Landscape connectivity, the extent to which a landscape facilitates the movements of organisms and their genes, faces critical threats from both fragmentation and habitat loss.
Beier, Paul, Cushman, Samual A, Dieffenbach, Fred, Epps, Clinton, Gerber, Leah R, Hartter, Joel N., Jenness, Jeff S, Kintsch, Julia, Merenlender, Adina M, Perkl, Ryan M, Perziosi, Damian V, Rudnick, Doborah, Ryan, Sadie J., Trombulack, Stephen C   +13 more
core   +1 more source

Effects of ocean sprawl on ecological connectivity: impacts and solutions [PDF]

, 2017
The growing number of artificial structures in estuarine, coastal and marine environments is causing “ocean sprawl”. Artificial structures do not only modify marine and coastal ecosystems at the sites of their placement, but may also produce larger-scale
Airoldi, L, Bishop, MJ, Chee, SY, Coleman, RA, Dafforn, KA, Firth, LB, Hawkins, SJ, Loke, LHL, Mayer-Pinto, M, Morris, RL, Naylor, LA   +10 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Eco-evolutionary dynamics in fragmented landscapes [PDF]

, 2017
Peer ...
Altermatt, Astegiano, Baguette, Baguette, Baguette, Becks, Bell, Bell, Bestion, Bestion, Bitume, Blanquart, Bocedi, Bocedi, Bonduriansky, Bonte, Burgess, Carazo, Cheptou, Cheviron, Clobert, Clobert, Clobert, Cook, Cote, Crespi, Cushman, Darwin, De Meester, Delgado, DiBattista, DiBattista, Dixo, Dobzhansky, Duputié, Edelaar, Edelaar, Ellner, Evans, Fahrig, Farkas, Farkas, Farkas, Fontúrbel, Frank, Fronhofer, Fronhofer, Fukami, Fussmann, Galtier, Gandon, Gandon, Garant, Garel, Ghalambor, Gomulkiewicz, Gomulkiewicz, Guillaume, Guillaume, Gyllenberg, Haddad, Haddad, Hand, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hartl, Hassell, Hendry, Hendry, Hendry, Hendry, Henry, Higgins, Holt, Holt, Holt, Hughes, Jacob, Kawecki, Keymer, Kinnison, Kronholm, Kubisch, Laughlin, Lechowicz, Legrand, Legrand, Legrand, Leibold, Leimu, Lenormand, Lewontin, Li, Li, Lohr, Lohr, Lopez, Low-Décarie, Lynch, Manel, Massot, Meester, Morris, Mouquet, Nadeau, Nee, North, Nosil, Orsini, Orsini, Pearse, Pelletier, Perrin, Phillips, Poethke, Poethke, Poethke, Post, Ravigné, Ravigné, Riba, Richardson, Ritchie, Robert, Robinson, Rodrigues, Roissart, Ronce, Ronce, Ronce, Rousset, Räsänen, Saastamoinen, Scheiner, Schoener, Schtickzelle, Schtickzelle, Shefferson, Shine, Stapley, Tack, Taylor, Taylor, Travis, Travis, Trochet, Turner, Urban, Urban, Vellend, Walser, Wheat, Wiegand, Wiens, Wilcove, Yeaman, Yoshida, Zheng   +163 more
core   +3 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source