Results 171 to 180 of about 439,531 (308)

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

open access: yesAdvanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph   +11 more
wiley   +1 more source

Landscape heterogeneity affects developmental and dispersal-related traits of a butterfly in agricultural landscapes. [PDF]

open access: yesEcol Appl
Deppe F   +16 more
europepmc   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

open access: yesAdvanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens   +3 more
wiley   +1 more source

Directly measuring single molecule heterogeneity using force spectroscopy

open access: yes, 2016
One of the most intriguing results of single molecule experiments on proteins and nucleic acids is the discovery of functional heterogeneity: the observation that complex cellular machines exhibit multiple, biologically active conformations.
Hinczewski, Michael   +2 more
core  

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

open access: yesAdvanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti   +27 more
wiley   +1 more source

Landscape aesthetics: towards a better understanding of rural landscape preferences [PDF]

open access: yes
The central aim of this study was to gain greater insights into the factors that affect individuals’ preferences for a variety of landscape settings. To achieve this aim, this paper derived dependent variables (based on a factor analysis of respondents ...
Howley, Peter
core   +1 more source

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