Results 101 to 110 of about 4,814,228 (287)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Analysis of Spatial Distribution and Impact Factors on Rural Settlement Based on Village Region—A Case Study of Balong Village in Lengshui Town, Shizhu County, Chongqing City

Shuitu baochi yanjiu, 2014
The spatial distribution adjustment and optimization of rural residential area,as one of the important contents of the new round of Overall Planning of Land Use, play an important part on the coordination on balance urban and rural development.
MIN Jie
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis on the Characteristics of the Landscape Pattern of Land Use in Tongnan County

Shuitu baochi yanjiu, 2005
Based on the information source of landscape map of 2000,the landscape indexes including characteristics of patch number,patch size,diversity index,evenness index and fragment index are calculated,analyzed and compared in order to disclose the spatial ...
HE Bing-hui~1, XU Xia~1, GU Shi-xian~2
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Complexity in landscape ecology

, 2020
This book examines key concepts and analytical approaches in complexity theory as it applies to landscape ecology, including complex networks, connectivity, criticality, feedback, and self-organisation.
Sadedin, Suzanne, Rimmington, Glyn M., Klomp, Nicholas, Green, David G.   +3 more
core  

Application of Ecological Quantitative Methods to Analyze Landscape Change in Forest Watershed

Shuitu baochi yanjiu, 2006
This study is to understand the impacts after landscape change of forest watershed（Chenyulian river）.The tendencies and source of these change patterns will be discussed and identical.Finally,the watershed land use management and planning strategies of ...
ZHANG Jun-bin~1, LIANG Da-qing~1, LIN Fa-qing~2, HUANG Yi-ru~2   +3 more
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Study on the Surface Landscape Changes in Fenhe River Basin of the Loess Plateau

Shuitu baochi yanjiu, 2013
The Loess Plateau is one of the most ecologically fragile regions in China.A case study was conducted in an independent basin unit in the eco-fragile region of the Fenhe River basin on the Loess Plateau based on Landsat-TM image respectively made in 2000
HOU Zhi-hua, MA Yi-juan
doaj