Results 111 to 120 of about 6,027,882 (331)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Free energy landscapes, dynamics and the edge of chaos in mean-field models of spin glasses

open access: yes, 2006
Metastable states in Ising spin-glass models are studied by finding iterative solutions of mean-field equations for the local magnetizations. Two different equations are studied: the TAP equations which are exact for the SK model, and the simpler `naive ...
A. J. Bray   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

LAND COVER TYPOLOGY USING GEOGRAPHIC INFORMATION SYSTEMS FOR ROMANIAN VITICULTURAL LANDSCAPE

open access: yesAgricultura, 2017
Viticultural landscapes traditionally consist of a diverse mosaic of different elements of agricultural and semi-natural ecosystems, providing a variety of ecosystem services.
Adela Hoble   +11 more
doaj   +1 more source

Genetic Land - Modeling land use change using evolutionary algorithms [PDF]

open access: yes
Future land use configurations provide valuable knowledge for policy makers and economic agents, especially under expected environmental changes such as decreasing rainfall or increasing temperatures, or scenarios of policy guidance such as carbon ...
Fernando Lobo   +4 more
core  

Ambienti umidi effimeri e naturalità del paesaggio in Sicilia [PDF]

open access: yes, 2009
This paper analyzes the relationship between vegetal communities conservation state and surrounding landscape naturalness. Expert-based assessment, based on phytosociological releves, has been used to define the qualitative condition of vegetal coenoses.
Baiamonte, G   +2 more
core  

Multidimensional optical fractionation with holographic verification

open access: yes, 2009
The trajectories of colloidal particles driven through a periodic potential energy landscape can become kinetically locked in to directions dictated by the landscape's symmetries.
B. W. Silverman   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Evaluation of Rice–Crayfish Field Fragmentation Based on Landscape Indices: A Case Study of Qianjiang City, China

open access: yesLand
Since the 21st century, rice–crayfish fields have been widely distributed in the Yangtze River Basin in China. However, the spontaneous construction of these fields by farmers has given rise to the issue of rice–crayfish field fragmentation (RCFF) in ...
Lei Shi, Xu He, Bo Hu, Jiuwei Li, Lei Yu
doaj   +1 more source

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