Results 51 to 60 of about 4,837,665 (286)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Perspective on the Refractive-Index Gas Metrology Data Landscape

Journal of Physical and Chemical Reference Data, 2021
The redefinition of the kelvin has increased focus on thermometry techniques that use the newly fixed value of the Boltzmann constant to realize thermodynamic temperature. One such technique that has advanced considerably in recent years is refractive-index gas thermometry.
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dynamic Landscape Fragmentation and the Driving Forces on Haitan Island, China

Land, 2022
Island ecosystems have distinct and unique vulnerabilities that place them at risk from threats to their ecology and socioeconomics. Spatially exhibiting the fragmentation process of island landscapes and identifying their driving factors are the ...
Jingwen Ai, Liuqing Yang, Yanfen Liu, Kunyong Yu, Jian Liu   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Science for action at the local landscape scale

, 2013
For landscape ecology to produce knowledge relevant to society, it must include considerations of human culture and behavior, extending beyond the natural sciences to synthesize with many other disciplines.
Liu, Jianguo, Albert, C., Nassauer, JI, Liu, J. G., Swaffield, Simon, Swaffield, SR, Opdam, Paul, McAlpine, C, Castella, J-C, Sheppard, S, Sheppard, Stephen, Nassauer, Joan Iverson, Nassauer, J. I., McAlpine, Clive, McAlpine, C., Bentrup, G, Wang, Z, Albert, C, Wang, Zhifang, Opdam, P, Opdam, P., Castella, Jean-Christophe, Swaffield, S., Liu, J, Bentrup, G., Albert, Christian, Wang, Z. F., Bentrup, Gary, Sheppard, S.   +28 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Landscape pattern evolution of the north of Hangzhou bay coastal area in Shanghai

上海师范大学学报. 自然科学版, 2012
Since the 1980s in Shanghai,fast economic development,rapid urbanization,population explosion,all of these phenomena are driving radical changes in landscape pattern of coastal area.The landscape pattern evolution at the coastal regions of the north of ...
LIANG Shuai, GAO Jun
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source