Results 101 to 110 of about 156,267 (264)

Reconciling natural habitat size loss and quality enhancement: the dual effects of urbanization in China’s Loess Plateau

Environmental Research Letters
Amid accelerating urbanization and severe biodiversity loss in global drylands, reconciling urbanization with habitat conservation is crucial for sustainable development.
Siya Li, Qiulei Ji, Wei Liang, Tingting Wang, Wenbin Liu, Hong Wang, Yao Feng, Fen Gou, Zhenguo Wang, Fubao Sun   +9 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Temporal and Spatial Changes of Soil Erosion and Its Response to Landscape Pattern in Dabie Mountains of Western Anhui in Recent 30 Years

Shuitu Baochi Xuebao
[Objective] The Dabie Mountain area in western Anhui Province is an important ecological transition area between the Yangtze River Basin and the Huaihe River Basin in Anhui Province.
TIAN Changyuan, ZHANG Hongli, WANG Junhong, LI Jianing, ZHANG Yi, ZHA Tonggang   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of landscape pattern change on waterbird diversity in Xianghai Nature Reserve

Open Geosciences
In order to study the change of landscape pattern and its impact on waterbird diversity in Xianghai Nature Reserve, this article analyzes the changing landscape pattern of the reserve from 2014 to 2017 at the landscape and type level. Pearson correlation
Zhao Yuelan, Liu Jiping, Li Huifen, Zhao Dandan   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The Landscape Resilience Index: a flexible tool for integrated landscape management

Frontiers in Sustainable Food Systems
Globally, landscapes are subject to intensifying and interacting environmental pressures, making landscape resilience increasingly important for sustaining ecosystem services, livelihoods, and long-term development. Integrated landscape management offers
W. Ovenden, E. Durrant, S. Ovenden, E. Ishengoma, S. Davis, M. A. Borges, M. Matediane, M. Esmael, C. Metta, A. Mhagama, A. Al Dwairi   +10 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

An Integrated Framework for Landscape Indices’ Calculation with Raster–Vector Integration and Its Application Based on QGIS

ISPRS International Journal of Geo-Information
Landscape-index calculation tools play a pivotal role in ecosystem studies and urban-planning research, enabling objective assessments of landscape patterns’ similarities and differences.
Yaqi Huang, Minrui Zheng, Tianle Li, Fei Xiao, Xinqi Zheng   +4 more
doaj   +1 more source

The landscape disparity index: an ecologically weigthed measure of the landscape diversity

, 2007
Typically, the analysis of landscape patterns is based on a quantitative analysis of the composition or/and the spatial arrangements of categorical units mapped from aerial photographs, satellite images or land use maps using so-called landscape metrics (Gustafson, 1998). Usually in landscape studies, authors assume that different landscape habitats or
openaire   +1 more source