Results 101 to 110 of about 177,351 (312)

Do greenness and landscape indices for greenspace correlate with suicide ratio?

, 2023
[[abstract]]Previous studies have demonstrated the preventive effects of greenness and greenspace using three classes of exposure metrics (greenspace coverage, greenness, and landscape indices for greenspace) on suicide.
Lee, HY;Chang, HT;Herianto, S;Wu, CS;Liu, WY;Yu, CP;Pan, WC;Wu, CD
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Greenways as strategic landscape planning: theory and application

, 2002
Greenways are systems and/or networks of protected lands that are managed for multiple uses including: nature protection, biodiversity management, water resources, recreation, and cultural/historic resource protection.
Ahern, J.F.
core  

Exploring Spatio-Temporal Variations of Ecological Risk in the Yellow River Ecological Economic Belt Based on an Improved Landscape Index Method. [PDF]

Int J Environ Res Public Health, 2023
Li M, Zhang B, Zhang X, Zhang S, Yin L.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Land use changes, landscape ecology and their socioeconomic driving forces in the Spanish Mediterranean coast (the Maresme County, 1850-2005)

, 2013
[cat] Utilitzem un conjunt de mètriques del paisatge per estudiar l'evolució a llarg termini seguida en una típica zona costanera del Mediterrani des de 1850 fins a 2005, que mostren una greu deterioració del medi ambient entre 1950 i 2005.
Marull, Joan, Pino i Vilalta, Joan, Parcerisas i Benedé, Lluís, 1978-, Coll, Francesc, Tello, Enric, Basnou, Corina   +5 more
core  

Evaluation of Rice–Crayfish Field Fragmentation Based on Landscape Indices: A Case Study of Qianjiang City, China

Land
Since the 21st century, rice–crayfish fields have been widely distributed in the Yangtze River Basin in China. However, the spontaneous construction of these fields by farmers has given rise to the issue of rice–crayfish field fragmentation (RCFF) in ...
Lei Shi, Xu He, Bo Hu, Jiuwei Li, Lei Yu
doaj   +1 more source

LAND COVER TYPOLOGY USING GEOGRAPHIC INFORMATION SYSTEMS FOR ROMANIAN VITICULTURAL LANDSCAPE

Agricultura, 2017
Viticultural landscapes traditionally consist of a diverse mosaic of different elements of agricultural and semi-natural ecosystems, providing a variety of ecosystem services.
Adela Hoble, Daniela Popescu, Claudiu Bunea, Francoise Burel, Muriel Guernion, Annegret Nicolai, Alben Fertil, Silvia Winter, Sophie Kratschmer, Johann Zaller, Gema Guzmán, Martin Potthoff   +11 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source