Results 81 to 90 of about 4,814,228 (287)

Spatial Pattern of Construction Land Distribution in Bays along the Coast of Vietnam

ISPRS International Journal of Geo-Information, 2020
Current studies of urban spatial morphology have rarely focused on the particularity of coastal cities, such as sea–land gradient features and bay types.
Junjue Zhang, Fenzhen Su
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessing Spatial Fragmentation: An Analysis Utilizing Multi-Source Data in Xi’an, China

ISPRS International Journal of Geo-Information
The urban fringe, a critical transitional zone between urban and rural areas, exhibits the most intense land-use conflicts and the most dynamic spatial restructuring.
Wenda Wang, Xiaoxiao Guo, Xuting Yang, Ning Zhang, Shaohua Wang, Zhenbo Wang, Liang Zhou, Chang Liu, Xiaojian Liang   +8 more
doaj   +1 more source

Exploring Spatio-Temporal Variations of Ecological Risk in the Yellow River Ecological Economic Belt Based on an Improved Landscape Index Method. [PDF]

Int J Environ Res Public Health, 2023
Li M, Zhang B, Zhang X, Zhang S, Yin L.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Landscape Change Index as a Tool for Spatial Analysis

IOP Conference Series: Materials Science and Engineering, 2017
This study analysed spatial and temporal changes in protected landscape of Ślęża Landscape Park in Poland, covering an area of 7724 ha. The main objective was to determine level of landscape change of the research area after Polish accession to European Union by comparing land-cover maps from 2004, 2009 and 2014.
Piotr Krajewski, Iga Solecka, Barbara Mastalska-Cetera   +2 more
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Landscape ecology integrates pattern and process in river corridors

, 1999
Landscape ecology holds the potential for developing a truly holistic perspective of river corridors, one that rigorously integrates structure, dynamics, and function.
Tockner, K. (author), Ward, J.V. (author), Malard, F. (author)   +2 more
core   +1 more source