Results 41 to 50 of about 5,508,906 (294)

Grain size effect of landscape in Jiangxi Guanshan subtropical evergreen broad-leaved forest

Guangxi Zhiwu
Determining an appropriate grain size is crucial in landscape pattern analysis and ecological research. In order to gain deeper insights into the spatial diversity and dynamic characteristics of landscape pattern, based on the survey data of the 12 hm2 ...
RAN Huan1, LAN Yong2, DAI Yufeng2, XIONG Yong2, WEN Renquan1, SONG Qingni1, YANG Qingpei1, LIU Jun1*
doaj   +1 more source

Evolution of landscape dynamics in the Yangtze River Delta from 2000 to 2020

Journal of Water and Climate Change, 2022
Based on the 2000–2020 land cover data, the landscape dynamics and landscape pattern index are used to study the landscape pattern changes of the Yangtze River Delta.
Zhe Chen Zhou, Jun Wang
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Many Perceptions, One Landscape [PDF]

, 2014
This paper relates an attempt to develop an integrated understanding of landscape values in the Akaroa Basin, in the South Island of New Zealand, as part of the author's PhD research. This case study sought to understand the landscape through the eyes of
Stephenson, Janet
core   +1 more source

Ecological impact assessment of road networks at landscape scale using spatial road disturbance index (SPROADI)

Journal of Environmental Engineering and Landscape Management, 2017
Development of roads can have deleterious effects on natural habitats containing species of conservation concern. Fragmentation of habitat into small, non-contiguous patches may result in dramatic population declinesthus appropriate studies quantifying ...
Shekoufeh Nematollahi, Sima Fakheran, Alireza Soffianian   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Science for action at the local landscape scale

, 2013
For landscape ecology to produce knowledge relevant to society, it must include considerations of human culture and behavior, extending beyond the natural sciences to synthesize with many other disciplines.
Liu, Jianguo, Albert, C., Nassauer, JI, Liu, J. G., Swaffield, Simon, Swaffield, SR, Opdam, Paul, McAlpine, C, Castella, J-C, Sheppard, S, Sheppard, Stephen, Nassauer, Joan Iverson, Nassauer, J. I., McAlpine, Clive, McAlpine, C., Bentrup, G, Wang, Z, Albert, C, Wang, Zhifang, Opdam, P, Opdam, P., Castella, Jean-Christophe, Swaffield, S., Liu, J, Bentrup, G., Albert, Christian, Wang, Z. F., Bentrup, Gary, Sheppard, S.   +28 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source