Results 41 to 50 of about 4,814,228 (287)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Perspective on the Refractive-Index Gas Metrology Data Landscape

Journal of Physical and Chemical Reference Data, 2021
The redefinition of the kelvin has increased focus on thermometry techniques that use the newly fixed value of the Boltzmann constant to realize thermodynamic temperature. One such technique that has advanced considerably in recent years is refractive-index gas thermometry.
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dynamic Landscape Fragmentation and the Driving Forces on Haitan Island, China

Land, 2022
Island ecosystems have distinct and unique vulnerabilities that place them at risk from threats to their ecology and socioeconomics. Spatially exhibiting the fragmentation process of island landscapes and identifying their driving factors are the ...
Jingwen Ai, Liuqing Yang, Yanfen Liu, Kunyong Yu, Jian Liu   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Science for action at the local landscape scale

, 2013
For landscape ecology to produce knowledge relevant to society, it must include considerations of human culture and behavior, extending beyond the natural sciences to synthesize with many other disciplines.
Liu, Jianguo, Albert, C., Nassauer, JI, Liu, J. G., Swaffield, Simon, Swaffield, SR, Opdam, Paul, McAlpine, C, Castella, J-C, Sheppard, S, Sheppard, Stephen, Nassauer, Joan Iverson, Nassauer, J. I., McAlpine, Clive, McAlpine, C., Bentrup, G, Wang, Z, Albert, C, Wang, Zhifang, Opdam, P, Opdam, P., Castella, Jean-Christophe, Swaffield, S., Liu, J, Bentrup, G., Albert, Christian, Wang, Z. F., Bentrup, Gary, Sheppard, S.   +28 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Practicing Landscape Field Guide No. 2: Landscapes of Energy and Extraction: Landscape as Archive

Practicing Landscape Field Guides are a series of publications that Reading Landscape has developed from a series of online seminars run during academic year 2021-22, entitled Practicing Landscape: Landscapes of Energy and Extraction.
Hale, Alex, Mersinis, Michael, Brind, Susan, Wall, Gina   +3 more
core   +4 more sources

Landscape pattern evolution of the north of Hangzhou bay coastal area in Shanghai

上海师范大学学报. 自然科学版, 2012
Since the 1980s in Shanghai,fast economic development,rapid urbanization,population explosion,all of these phenomena are driving radical changes in landscape pattern of coastal area.The landscape pattern evolution at the coastal regions of the north of ...
LIANG Shuai, GAO Jun
doaj