Results 71 to 80 of about 4,837,665 (286)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Distribution Characteristics of Mountainous and Hilly Areas of Rural Settlements Space
Shuitu baochi yanjiu, 2014 The purpose of this paper is to reveal the spatial distribution characteristics of rural settlements in mountainous and hilly area in China.The research methods include landscape index analysis,spatial autocorrelation analysis and spatial analysis.The ...
LIU Mei-rong, GUAN Xin, LI Qiao-yun
doaj
Indexing the vulnerability of biotopes to landscape changes
Ecological Indicators, 2019 Abstract Biodiversity loss is one of the great challenges of our times, and it is primarily driven by losses of natural and semi-natural areas. To avoid further biodiversity losses, landscape planning and ecosystem management could benefit from a condensed measure that tracks regional and cumulative ecological degradation from past and ongoing ...
openaire +1 more source
A Study on Application of Landscape Diagnosis Index and Landscape Formation Plan of Rural Villages
Journal of Korean Society of Rural Planning, 2013 In this study, it propose what the landscape elements is to be improved urgently and how to improve landscape by reflecting the rural village characteristics away from the spatial integrated landscape planning. The study area for landscape research is selected as the 9 rural villages in Chungcheongbuk-do, and research is done by using village unit ...
Hee-Jung Song +3 more
openaire +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Shuitu baochi yanjiu, 2014 Caofeidian area in Tangshan City was taked as the study area,and by using remote sensing,geographic information system and global positioning system technology methods,based on landscape ecology theory combined with the method of principal component from
WANG Guan-yong +4 more
doaj
Shuitu Baochi Xuebao[Objective] Chongqing is a mega-metropolis located in the southwestern hilly region. The rising population and extensive economic development have led to rapid urban landscape ascent and expansion, resulting in a dual urban-rural and 3D spatial structure
WEI Mengyu +6 more
doaj +1 more source
ISPRS International Journal of Geo-Information, 2019 Comparisons of the accuracy and consistency of different remote-sensing land cover datasets are important for the rational application of multi-source land cover datasets to regional development, or to studies of global or local environmental change ...
Junmei Kang +5 more
doaj +1 more source
The Landscape Resilience Index: a flexible tool for integrated landscape management
Frontiers in Sustainable Food SystemsGlobally, landscapes are subject to intensifying and interacting environmental pressures, making landscape resilience increasingly important for sustaining ecosystem services, livelihoods, and long-term development. Integrated landscape management offers a promising approach to strengthening resilience, yet many existing monitoring frameworks are not ...
W. Ovenden +10 more
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source