Results 251 to 260 of about 872,744 (314)

Progranulin Deficiency Improves Metabolic Stress Yet Falls Short of Sodium-Glucose Cotransporter-2 Inhibition in Autophagy-Linked Renal Protection. [PDF]

Endocrinol Metab (Seoul)
Im SS.
europepmc   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Spatial influencing factors and protection strategies of traditional villages in ethnic areas: A case study of Guangxi. [PDF]

PLoS One
Tan J, Liu J, Zou Y, Wei X.
europepmc   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Conservation Hotspots of <i>Quercus castaneifolia</i> Revealed Through the Integration of Genetic Diversity and Landscape Connectivity. [PDF]

Ecol Evol
Shahnaseri G, Malekian M, Müller M, Gailing O.   +3 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Multiscale Nest-Site Selection of Burrowing Owl (<i>Athene cunicularia</i>) in Chihuahuan Desert Grasslands. [PDF]

Biology (Basel)
Ruiz Aymá G, Olalla Kerstupp A, Gómez Govea MA, Guzmán Velasco A, González Rojas JI.   +4 more
europepmc   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Effects of landscape pattern changes on ecosystem services: a case study of Ruoergai Plateau. [PDF]

Sci Rep
Zhou J, Chen W, Cai Y, Meng Y, Wang Y, Liu Q, Luo S, Peng J.   +7 more
europepmc   +1 more source

Evaluating and optimizing ecological networks in the Hubei Yangtze river economic belt using an importance-sensitivity and circuit-graph approach. [PDF]

Sci Rep
Zeng J, Li S.
europepmc   +1 more source