Results 191 to 200 of about 432,625 (307)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

What Does the Shape Space of T Cell Epitopes Look Like? [PDF]

Immunol Rev
Buytenhuijs F, Schröder G, Textor J.
europepmc   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Intensive arable farming calls for resilient wild bee restoration amid severe abundance fluctuations. [PDF]

Ecol Appl
Piross IS, Bihaly ÁD, Szigeti V, Arany I, Demeter I, Kőhalmi F, Lellei-Kovács E, Máté A, Németh VE, Pellaton R, Sárospataki M, Soltész Z, Somay L, Stephenson DL, Szabó K, Tanács E, Teplánszki D, Vajna F, Zsinka B, Kovács-Hostyánszki A, Báldi A.   +20 more
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Evaluation of visual landscape quality in Global Geopark based on an SBE-GIS coupled model. [PDF]

PLoS One
Guo H, Chen C, Huang L.
europepmc   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Semi-Natural Habitats Buffer the Effects of Crop Diversification on Arthropod Pest Control Services in Agricultural Landscapes. [PDF]

Ecol Lett
Perrot T, Beaumelle L, Thomine E, Tricault Y, Desneux N, Albrecht M, Batáry P, Bianchi F, Birkhofer K, Bosem Baillod A, Chaplin-Kramer R, Cortesero AM, Costamagna AC, Diekötter T, Ekroos J, Entling MH, Gagic V, Groves R, Huseth A, Jaworski C, Kaiser M, Karp DS, Krauss J, Lavandero B, Le Ralec A, Lu Y, Martin EA, Mitchell M, Molina GAR, Palmu E, Perovic DJ, Ragsdale D, Redlich S, Samaranayake I, Saulais J, Schellhorn NA, Steffan-Dewenter I, Sutter L, Tscharntke T, Tschumi M, Rusch A.   +40 more
europepmc   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Restorative effects of plant landscapes under different weather and phenology conditions: evidence from EEG and psychological responses. [PDF]

Sci Rep
Zhao Y, Wei J, Zhong Y, Luo M, Wu J.
europepmc   +1 more source