Results 141 to 150 of about 1,241,748 (389)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
PRICE AND NON-PRICE INFLUENCES ON WATER CONSERVATION: AN ECONOMETRIC MODEL OF AGGREGATE DEMAND UNDER NONLINEAR BUDGET CONSTRAINT [PDF]
We study the influence of prices and non-price conservation programs on water consumption and conservation behavior during a drought in the San Francisco Bay Area.
Corral, Leonardo +2 more
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Town of Hampton Stormwater Management PREP Natural Resources Outreach Coalition Grant Final Project Report [PDF]
, 2010 PREP provided $3,500 towards the project which was matched by municipal funds to pay for consulting advice on improving the regulations. The Planning Board provided exceptional in-kind match on the project, with many hours of work spent by a volunteer ...
Natural Resources Outreach Coalition +1 more
core +2 more sources
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Wetland Buffer Characterization and Public Outreach in North Hampton [PDF]
, 2008 This report includes a characterization of wetland buffers and buffer protection in North Hampton and a community outreach newsletter that focuses on the protection of the North Hampton wetland buffers.
Kellam, Dave
core +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Conspectus and the Scottish Collections Network : landscaping the Scottish common information environment [PDF]
, 2006 The article briefly gives the background to the concept of a common information environment, followed by a history of the development of two major components of a common information environment for Scotland in the form of the Scottish Collections Network,
Dunsire, Gordon
core +2 more sources
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Future information environments: deserts, jungles or parks? [PDF]
, 2006 This paper discusses the basic functions of a common information environment and how they are supported by metadata. Several distinct categories of information landscapes are described, characterised by the availability and quality of metadata at the ...
Dunsire, Gordon
core +1 more source