Results 141 to 150 of about 54,115 (209)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Empirical study of lane-changing behavior on three Chinese freeways. [PDF]

PLoS One, 2018
Guo M, Wu Z, Zhu H.
europepmc   +1 more source

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

Conditional Artificial Potential Field-Based Autonomous Vehicle Safety Control with Interference of Lane Changing in Mixed Traffic Scenario. [PDF]

Sensors (Basel), 2019
Gao K, Yan D, Yang F, Xie J, Liu L, Du R, Xiong N.   +6 more
europepmc   +1 more source

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Lane changing trajectory planning and tracking control for intelligent vehicle on curved road. [PDF]

Springerplus, 2016
Wang L, Zhao X, Su H, Tang G.
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Enhancing Sustainability Label Effectiveness Through Logo Design Modification: An Analysis of the EU Green Leaf Logo

Agribusiness, EarlyView.
ABSTRACT Sustainability labels can help support consumers select more socially and environmentally friendly options, thereby enhancing returns for conscientious producers and promoting the transition to a more sustainable food system. However, consumer confusion regarding labels' meaning undermines their effectiveness.
Monika Hartmann, Ching‐Hua Yeh, Matthew Gorton, Barbara Tocco, Áron Török   +4 more
wiley   +1 more source

Lidar‐Based Object Tracking of Traffic Participants with Sensor Nodes in Existing Urban Infrastructure

Advanced Intelligent Systems, EarlyView.
This paper presents a lidar‐based sensor node design and a rule‐based state observer for edge‐based traffic participant tracking. Unlike other state‐of‐the‐art methods, this state observer enables real‐time, CPU‐only edge processing without relying on machine learning approaches.
Simon Schäfer, Bassam Alrifaee, Ehsan Hashemi   +2 more
wiley   +1 more source

Driver Behavior Modeling with Subjective Risk‐Driven Inverse Reinforcement Learning

Advanced Intelligent Systems, EarlyView.
A subjective risk‐driven inverse reinforcement learning framework is proposed to model driver decision‐making. It infers drivers' risk perception and risk tolerance from driving data. A learnable risk threshold is used to regulate decisions, enabling interpretable and human‐like driving behavior decisions.
Yang Liang, Zichao Wang, Zhiwei He, Qingquan Wei, Yong Zuo, Linzhen Nie, Zhishuai Yin   +6 more
wiley   +1 more source