Results 31 to 40 of about 51,953 (228)

Primary oral manifestation of Langerhans cell histiocytosis refractory to conventional therapy but susceptible to BRAF-specific treatment: a case report and review of the literature [PDF]

, 2019
Langerhans cell histiocytosis (LCH) is a diagnostic and therapeutic challenge. We report on a rare case of its primary oral manifestation that was treated successfully with the BRAF-specific agent, vemurafenib, after insufficient standard LCH treatment ...
Beck-Broichsitter, Benedicta, Doueiri, Mohemed-Salim, Heiland, Max, Lissat, Andrej, Neckel, Norbert, Raguse, Jan-Dirk, Spors, Birgit, Stackelberg, Arendt von, Thieme, Nadine   +8 more
core   +1 more source

An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis [PDF]

, 2016
We report a case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH). It is known that LCH has a predilection for intertriginous areas, however purely cutaneous disease as in our case, is uncommon ...
Baldacchino, Godfrey, Betts, Alexandra, Boffa, Michael J., Gatt, Alex   +3 more
core  

Epigenomics and Single-cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis.

Cancer Discovery, 2019
Langerhans cell histiocytosis (LCH) is a rare neoplasm predominantly affecting children. It occupies a hybrid position between cancers and inflammatory diseases, which makes it an attractive model for studying cancer development. To explore the molecular
F. Halbritter, Matthias Farlik, Raphaela Schwentner, G. Jug, N. Fortelny, Thomas Schnoller, Hanja Pisa, L. Schuster, A. Reinprecht, T. Czech, J. Gojo, W. Holter, M. Minkov, W. Bauer, I. Simonitsch-Klupp, C. Bock, C. Hutter   +16 more
semanticscholar   +1 more source

Langerhans cell histiocytosis

, 2013
Definition: A histiocytary proliferation of granuloma-like aspect with unknown etiology that may involve bone marrow, internal organs, skin, and mucosae.
openaire   +4 more sources

Multisystem Langerhans cell histiocytosis coexisting with metastasizing adenocarcinoma of the lung: A case report [PDF]

, 2013
Introduction. Langerhans cell histiocytosis (LCH) is an uncommon disease of unknown etiology characterized by uncontrolled proliferation and infiltration of various organs by Langerhans cells. Case report. We presented a 54-year-old man, heavy smoker,
Eri Živka, Klem Ištvan, Lovrenski Aleksandra, Panjković Milana, Považan Đorđe, Tegeltija Dragana, Đurić Mirna   +6 more
core   +1 more source

RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Journal of Experimental Medicine, 2018
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling ...
Brandon Hogstad, M. Berres, Rikhia Chakraborty, Jun Tang, Camille Bigenwald, Madhavika N. Serasinghe, Karen Phaik Har Lim, Howard Lin, T. Man, R. Remark, Samantha Baxter, V. Kana, Stefan Jordan, Zoi Karoulia, Wing-hong Kwan, M. Leboeuf, E. Brandt, Hélène Salmon, K. McClain, Poulikos I. Poulikakos, J. Chipuk, W. Mulder, C. Allen, M. Merad   +23 more
semanticscholar   +1 more source

Langerhans Cell Histiocytosis of the Tonsil

Balkan Medical Journal, 2022
Langerhans cell histiocytosis (LCH) is a rare disease that is characterized by clonal neoplastic proliferation of the dendritic Langerhans cells. LCH presents either with solitary or multiple organ involvement.1,2 The most commonly affected organs include the bones, skin, and pituitary gland; the hematopoietic system, lymph nodes, and lungs are rarely ...
Federica Cipolla , Martina Ragusa , Vittoria Bannò, Ignazio La Mantia , Claudio Andaloro   +4 more
openaire   +4 more sources

Genetic landscape of adult Langerhans cell histiocytosis with lung involvement

European Respiratory Journal, 2019
The clinical significance of the BRAFV600E mutation in adult Langerhans cell histiocytosis (LCH), including pulmonary Langerhans cell histiocytosis (PLCH), is not well understood. Similarly, the spectrum of molecular alterations involved in adult LCH has
F. Jouenne, S. Chevret, E. Bugnet, E. Clappier, G. Lorillon, V. Meignin, A. Sadoux, S. Cohen, A. Haziot, A. How-Kit, C. Kannengiesser, C. Lebbé, D. Gossot, S. Mourah, A. Tazi   +14 more
semanticscholar   +1 more source

A Case of Refractory Langerhans Cell Histiocytosis Complicated with Hemophagocytic Lymphohistiocytosis Rescued by Cord Blood Transplantation with Reduced-intensity Conditioning [PDF]

, 2017
　We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy ...
Kanamitsu, Kiichiro, Muraoka, Michiko, Oda, Megumi, Shimada, Akira, Washio, Kana   +4 more
core   +1 more source

BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy.

Journal of Clinical Oncology, 2016
PURPOSE Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with a broad spectrum of clinical manifestations and outcomes in children.
S. Héritier, J. Emile, M. Barkaoui, C. Thomas, S. Fraitag, S. Boudjemaa, F. Renaud, A. Moreau, M. Peuchmaur, C. Chassagne‐Clément, F. Dijoud, V. Rigau, D. Moshous, A. Lambilliotte, F. Mazingue, K. Kébaili, Jean Miron, E. Jeziorski, G. Plat, N. Aladjidi, A. Ferster, H. Pacquement, C. Galambrun, L. Brugières, G. Leverger, L. Mansuy, C. Paillard, A. Deville, C. Armari‐Alla, A. Lutun, Marion Gillibert-Yvert, J. Stéphan, F. Cohen-Aubart, J. Haroche, I. Pellier, F. Millot, B. Lescoeur, V. Gandemer, C. Bodemer, R. Lacave, Z. Hélias‐Rodzewicz, V. Taly, F. Geissmann, J. Donadieu   +43 more
semanticscholar   +1 more source