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Langerhans cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes, skin, and mucosa.
Sushma Galgali+3 more
openaire +3 more sources
Pulmonary Langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child
Bilateral pneumothorax is very rare in childhood. Moreover, if it is due to pulmonary involvement of Langerhans cell histiocytosis, it is even rarer in childhood.
Anupam Patra+3 more
doaj +1 more source
Objective: Langerhans cell histiocytosis is an unusual disorder of unknown etiology with heterogeneous clinical behaviors and variable outcomes. It can involve one or more organs or systems, but to our best knowledge, parotid glands involvement in ...
Xiaojun Yuan+4 more
doaj +1 more source
PURPOSE Off-label use of vemurafenib (VMF) to treat BRAFV600E mutation–positive, refractory, childhood Langerhans cell histiocytosis (LCH) was evaluated. PATIENTS AND METHODS Fifty-four patients from 12 countries took VMF 20 mg/kg/d. They were classified
J. Donadieu+45 more
semanticscholar +1 more source
Langerhans cell sarcoma of the skin is a rare tumor with aggressive behavior. There are reports of Langerhans cell sarcoma involving the skin in patients with underlying systemic Langerhans cell histiocytosis.
Alejandro Peralta Soler+2 more
doaj +1 more source
Three cases of congenital self‐healing Langerhans cell histiocytosis with BRAF‐V600E mutation
Congenital self‐healing Langerhans cell histiocytosis (CSHLCH) is a rare variant of Langerhans cell histiocytosis characterised by the presence of skin lesions in the neonate and spontaneous self‐healing after a variable period of time.
Mar Ramírez‐Lluch+7 more
doaj +1 more source
Shaping bursting by electrical coupling and noise [PDF]
Gap-junctional coupling is an important way of communication between neurons and other excitable cells. Strong electrical coupling synchronizes activity across cell ensembles. Surprisingly, in the presence of noise synchronous oscillations generated by an electrically coupled network may differ qualitatively from the oscillations produced by uncoupled ...
arxiv +1 more source
Recurrent adult-onset hypophyseal Langerhans cell histiocytosis after radiotherapy: A case report [PDF]
INTRODUCTION: Langerhans cell histiocytosis is a rare disease within the adult population, with very few cases reported as solitary hypophyseal lesions in adults.
Chicoine, Michael R+8 more
core +2 more sources
Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response [PDF]
Cells of almost all solid tissues are connected with gap junctions which permit the direct transfer of ions and small molecules, integral to regulating coordinated function in the tissue. The pancreatic islets of Langerhans are responsible for secreting the hormone insulin in response to glucose stimulation.
arxiv +1 more source
The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on $\textrm{Ca}^{2+}$ dynamics [PDF]
Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $\beta$-cell mass and alteration of $\beta$-cell function in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. The mechanisms for deficiency in $\beta$-cell mass and function during the hyperglycemia development and T2D ...
arxiv +1 more source