Results 51 to 60 of about 257,786 (259)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Electronic L1 and L2 glosses’ impact on vocabulary acquisition of Moroccan English as a foreign language learners

Australian Journal of Applied Linguistics
With the growing interest in integrating ICT in the EFL classroom, the present study investigates the impact of electronic first language (L1) translations and second language (L2) definitions glosses on incidental vocabulary learning and retention among
BrahiM OutamghartE, Mohamed Yeou, Hicham Zyad   +2 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Exploring the relationships between ASS indices and CAF and the impact on Chinese college students’ oral English performance

Language Testing in Asia
Automatic Speech Scoring (ASS) has increasingly become a useful tool in oral proficiency testing for Second Language (L2) learners. However, limited studies investigate the alignment of ASS indices with the Complexity, Accuracy, and Fluency (CAF)—the ...
Xiaoqin Shi, Xiaoqing Wang, Wei Zhang
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Occupational gender segregation and gendered language in a language without gender: trends, variations, implications for social development in China

Humanities & Social Sciences Communications, 2021
This paper proposes a textual analytics approach to the discovery of trends and variations in social development. Specifically, we have designed a linguistic index that measures the marked usage of gendered modifiers in the Chinese language; this ...
Qi Su, Pengyuan Liu, Wei Wei, Shucheng Zhu, Chu-Ren Huang   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Credit Risk Assessment of Green Supply Chain Finance for Logistics Enterprises: A Comparative Study of Logistic Model and BP Neural Network

SAGE Open
With the escalating global emphasis on sustainable development, Green Supply Chain Finance (GSCF) has emerged as a critical area of interest for academic researchers, industry practitioners, and policy makers alike.
Lan Wang, Yingcheng Zheng, Yudong Yang, Xiangming Zeng, Jingyi Chen   +4 more
doaj   +1 more source

Research on Climactic Chapter Recognition of a Chinese Long Novel Based on Plot Description

Applied Sciences
Many readers continue to pursue Chinese long novels in the past several decades because of diverse characters and fascinating plots. The climactic chapter is an important part of a Chinese long novel, where the key conflict develops to the extreme point.
Zhongbao Liu, Guangwen Wan, Yingbin Liu, Jianan Hu   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source