Results 301 to 310 of about 10,571,585 (371)

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

MGPT: A Multi‐task Graph Prompt Learning Framework for Drug Discovery

Advanced Science, EarlyView.
MGPT is a unified multi‐task graph prompt learning model providing generalizable and robust graph representations for few‐shot drug association prediction. MGPT demonstrates the ability of seamless task switching and outperforms competitive approaches in few‐shot scenarios.
Yang Li, Youhan Sun, Xinyu Qin, Xin Gao, Guohua Wang   +4 more
wiley   +1 more source

Wide Linearity Range and Rapid‐Response Tactile Sensor Inspired by Parallel Structures

Advanced Science, EarlyView.
Inspired by parallel structures, a composite tactile sensor design is proposed using parallel elastomer integration, developing two novel sensors. This strategy optimizes the force‐electric response and viscoelastic hysteresis of the conductive composite, achieving a balanced enhancement of linear sensing range and fast response.
Weihua Gao, Jiantao Yao, Xianhe Yu, Guoliang Ma, Dakai Wang, Hongnian Yu, Zhiwu Han, Luquan Ren   +7 more
wiley   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

Advanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou, Wenli Zhao, Yihan Zhu, Hongyan Liu, Yicheng Sun, Zhengrong Gong, Xuanyi Li, Ziying Liu, Kang Wen, Yicheng Wang, Jie Ren, Ruipei Xiao, Ling Jiang, Yanfeng Hu, Enguang Bi, Xiaoyong Zhang   +15 more
wiley   +1 more source

HDML: an Object-Oriented Hyper-document Descripting Meta Language for E-education

, 2003
Yolaine Bourda, Bich-Liên Doan, Henri Delebecque   +2 more
openalex   +1 more source

Prospect of Cascade Catalysis in Magnesium‐Sulfur Batteries from Desolvation to Conversion Reactions

Advanced Science, EarlyView.
The dissolution and conversion reactions at the cathode interface of Mg‐S batteries are systematically summarized. This review focuses on the problems and solutions of diffusion/desolvation Mg2+ migration barrier at the sulfur/electrolyte interface as well as the current development and design of S cathodes in Mg‐S batteries under catalysis ...
Qinghua Guan, Jing Zhang, Yongzheng Zhang, Xiaomin Cheng, Jing Dong, Lujie Jia, Hongzhen Lin, Jian Wang   +7 more
wiley   +1 more source

High‐Performance Conductive Elastomers Based on Deep Eutectic Solvents and Polyvinyl Alcohol for Flexible Monitoring Sensors

Advanced Electronic Materials, EarlyView.
A novel conductive elastomer is developed by incorporating deep eutectic solvents into a PVA/Polyacrylic Acid (PAA) network. The synergistic effects of dynamic hydrogen bonds, ionic interactions, and chemical crosslinking result in a highly flexible and dense polymer structure, while the integration of sodium chloride ensures excellent conductivity and
Pinwen Wang, Shouhua Han, Zhipeng Hou, Sihang Ren, Muxin Zhao, Liqun Yang   +5 more
wiley   +1 more source