Results 301 to 310 of about 10,571,585 (371)

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

open access: yesAdvanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu   +11 more
wiley   +1 more source

MGPT: A Multi‐task Graph Prompt Learning Framework for Drug Discovery

open access: yesAdvanced Science, EarlyView.
MGPT is a unified multi‐task graph prompt learning model providing generalizable and robust graph representations for few‐shot drug association prediction. MGPT demonstrates the ability of seamless task switching and outperforms competitive approaches in few‐shot scenarios.
Yang Li   +4 more
wiley   +1 more source

Wide Linearity Range and Rapid‐Response Tactile Sensor Inspired by Parallel Structures

open access: yesAdvanced Science, EarlyView.
Inspired by parallel structures, a composite tactile sensor design is proposed using parallel elastomer integration, developing two novel sensors. This strategy optimizes the force‐electric response and viscoelastic hysteresis of the conductive composite, achieving a balanced enhancement of linear sensing range and fast response.
Weihua Gao   +7 more
wiley   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

open access: yesAdvanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang   +7 more
wiley   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He   +11 more
wiley   +1 more source

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou   +15 more
wiley   +1 more source

Prospect of Cascade Catalysis in Magnesium‐Sulfur Batteries from Desolvation to Conversion Reactions

open access: yesAdvanced Science, EarlyView.
The dissolution and conversion reactions at the cathode interface of Mg‐S batteries are systematically summarized. This review focuses on the problems and solutions of diffusion/desolvation Mg2+ migration barrier at the sulfur/electrolyte interface as well as the current development and design of S cathodes in Mg‐S batteries under catalysis ...
Qinghua Guan   +7 more
wiley   +1 more source

High‐Performance Conductive Elastomers Based on Deep Eutectic Solvents and Polyvinyl Alcohol for Flexible Monitoring Sensors

open access: yesAdvanced Electronic Materials, EarlyView.
A novel conductive elastomer is developed by incorporating deep eutectic solvents into a PVA/Polyacrylic Acid (PAA) network. The synergistic effects of dynamic hydrogen bonds, ionic interactions, and chemical crosslinking result in a highly flexible and dense polymer structure, while the integration of sodium chloride ensures excellent conductivity and
Pinwen Wang   +5 more
wiley   +1 more source

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