Results 61 to 70 of about 120,594,295 (222)

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Language, strategy, and influence: a pragmatic analysis of Indonesian YouTube influencers and their impact on social media

open access: yesCogent Arts & Humanities
The pragmatic aspects of communication among Indonesian YouTube influencers and the people have given birth to interactive communication. This study aims to examine the function of pragmatics in Indonesian podcasts with focus on speech acts, speech ...
Indah Rahmayanti   +3 more
doaj   +1 more source

Popoia te reo kia penapena: Nurture the language [PDF]

open access: yes, 2009
Research to develop a Māori language screening tool (Specialist Education Services, 2001), identified that students entering Māori Medium at five, could be classified into one of four Māori language competency, groups. Concurrently, teachers raised their
Glynn, Ted   +4 more
core  

Teaching strategies and materials in foreign language teaching in Finland: Focus on basic and upper secondary education [PDF]

open access: yes
The purpose of this study was to investigate what teaching strategies and materials are used in foreign language education in Finland. The data were collected with an online questionnaire that was answered by 550 language teachers from primary school to ...
Luodonpää-Manni, Milla Kaarina   +4 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

EFL student teachers’ AI self-efficacy across different countries

open access: yesAsian-Pacific Journal of Second and Foreign Language Education
The rapid advancement of artificial intelligence (AI) in education has identified the need to understand how future educators perceive and engage with these technologies. This study investigates the AI self-efficacy of English as a Foreign Language (EFL)
Zdena Kralova   +5 more
doaj   +1 more source

Language Education, Gender, and Sexuality

open access: yes, 2017
In this chapter we provide an overview of theory and research conducted over the past few decades on language education and gender. In addition, we bring this overview of the field up to date by including more recent work on sexuality.
Benedict Rowlett   +3 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

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