Results 11 to 20 of about 2,955,194 (245)
Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022 Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima +9 more
wiley +1 more source
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022 Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino +16 more
wiley +1 more source
Space, Time and Motion in Czech as a Second Language [PDF]
Studie z Aplikované Lingvistiky, 2020 The introductory study deals with two main topics that are relevant to the given special issue: a) changes which the research in the study of the conceptualisation of motion events, space and time and the ways and means of their expression in language in
Karel Šebesta
doaj
Categories of Space and Time in the Christian Supertext of the Explanatory Dictionary
Известия Уральского федерального университета. Серия 2: Гуманитарные науки, 2022 This article examines religious terminology (religious vocabulary recorded in explanatory dictionaries of the Russian literary language) from the standpoint of the categorial-textual approach.
Julia Nikolaevna Mikhailova
doaj +1 more source
The Thaayorre think of time like they talk of space
Frontiers in Psychology, 2012 Around the world, it is common to both talk and think about time in terms of space. But does our conceptualization of time simply reflect the space/time metaphors of the language we speak? Evidence from the Australian language Kuuk Thaayorre suggests not.
Alice eGaby
doaj +1 more source
Fictional metaphysics of fiction: Metaphysics and imagination in the humanities
HTS Teologiese Studies/Theological Studies, 2017 A very simplified description of physics could be, according to Wikipedia, natural science that involves the study of matter and its motion and behaviour through space and time.
Johann-Albrecht Meylahn
doaj +1 more source
IEEE Access, 2021 The wide application of Cyber Physical System (CPS) makes the security of CPS more and more concerned. As the key factors affecting the safety of CPS, space and time have also become the current research hotspot. The space and time safety of CPS requires
Xiaoying Chen +4 more
doaj +1 more source
Discursive Features of Russian as a Foreign Language Textbooks: Respond to Negative Russia Image Stereotypes [PDF]
ARPHA Proceedings, 2021 The article analyses the didactic space of the Russian as a foreign language textbooks and manuals within the pedagogical discourse in terms of intercultural communication theory.
Svetlana Gerasimova, Natalia Kasyanova
doaj +3 more sources