Results 101 to 110 of about 8,355,780 (302)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Investigação histórica do bilinguismo na Península Ibérica a partir do século XV – até ao século XVII

Études romanes de Brno, 2009
The aim of the present paper is to give a historical and linguistic overview of the peculiar bilingual period in the Iberian Península in the 16th and 17th centuries, followed by historical, cultural and social background describing language behaviour ...
Ildikó Haffner
doaj  

Negative Interference from Russian in Czech as a Second Language: Error Analysis of the Copula and Auxiliary Verb in Russian Speakers

ACC Journal
Language interference is a key challenge in foreign language acquisition. When learning a second language, students transfer the knowledge from their mother tongue.
Matyášková Gabriela
doaj   +1 more source

Interference of Thai Language on Dialectal Variations of Jawi Malay in Narathiwat

Journal of Languages and Language Teaching
The connection between language and culture becomes increasingly evident when the Thai language influences the variations of Jawi Malay dialects in Narathiwat.
Indra Hadinata Rambe, Suhailee Sohnui, Khairunnisah Khairunnisah, Nikmah Sari Hasibuan, Eli Marlina Harahap   +4 more
doaj   +1 more source

Syllable Structure Universals and Native Language Interference in Second Language Perception and Production: Positional Asymmetry and Perceptual Links to Accentedness

Frontiers in Psychology, 2015
The present study investigated how syllable structure differences between the first Language (L1) and the second language (L2) affect L2 consonant perception and production at syllable-initial and syllable-final positions.
Bing Cheng, Y. Zhang
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Interferensi Gramatika Maharah Kitabah dan Penyebabnya Pada Mahasiswa Pascasarjana UIN Sunan Kalijaga

Arabiyatuna: Jurnal Bahasa Arab, 2020
The purpose of this research is to find out the forms of grammatical interference that occur in graduate students of UIN Sunan Kalijaga. Interference is a language disorder that often occurs for language learners.
Ariadi Muliansyah, R Umi Baroroh
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source