Results 61 to 70 of about 59,382 (260)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Language Preservation Problems in Parametric Timed Automata

Logical Methods in Computer Science, 2020
Parametric timed automata (PTA) are a powerful formalism to model and reason about concurrent systems with some unknown timing delays. In this paper, we address the (untimed) language- and trace-preservation problems: given a reference parameter valuation, does there exist another parameter valuation with the same untimed language, or with the same set
André, Étienne, Lime, Didier, Markey, Nicolas   +2 more
openaire   +5 more sources

Exploring the Role of African Indigenous Cultural Performances in Language Revitalisation and Preservation: A Case study of Xhosa, Maasai & Yorùbá

Open Cultural Studies
In the face of increasing alarm at the rapid rate of endangerment of the many Indigenous languages of Africa, with over 2,000 languages facing extinction, this study argues for a critical role for oral performance genres not only as cultural expressions ...
Ohenhen Stanley Timeyin, Ohenhen Martina Abiodun, Manyasi Beatrice N., Abakporo Princewill Chukwuma, Egbe Fidelis Enang, Faniyi Ooreofe-kristi, Eze Michael Nwali, Oladele Olayiwola   +7 more
doaj   +1 more source

Developing the Corpus of Minangkabau Language: Insights, Challenges, and Future Directions

Arbitrer
This paper discusses the design for developing the Minangkabau language corpus, especially regarding the opportunities and challenges. The corpus development of Minangkabau is a crucial project to document, preserve, and revive the treasure trove of ...
Handoko Handoko
doaj   +1 more source

Ainu–Japanese Bi-directional Neural Machine Translation: A Step Towards Linguistic Preservation of Ainu, An Under-Resourced Indigenous Language in Japan [PDF]

Journal of Data Mining and Digital Humanities
This study presents a groundbreaking approach to preserving the Ainu language, recognized as critically endangered by UNESCO, by developing a bi-directional neural machine translation (MT) system between Ainu and Japanese.
So Miyagawa
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source