Results 81 to 90 of about 309,043 (266)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Türkçe Öğretmeni Adaylarının Soru Hazırlamaya Dair Deneyim ve Görüşleri

Ana Dili Eğitimi Dergisi
Ana dili eğitiminin temel amacı anlama ve anlatma becerilerini geliştirmektir. Ana dili derslerinde sorulan sorular hem anlama (okuma ve dinleme) ve anlatma (konuşma ve yazma) becerilerinin geliştirilmesi hem de bu becerilerin ölçülmesi ve ...
Duygu Yüceer
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Analysis of the Arabic Language Skills Curriculum in Arabic Education Department in the Perspective of Common European Framework of Reference for Languages (CEFR)

Asalibuna
: The application of the CEFR in teaching Arabic, especially in non-Arab countries such as Indonesia, remains very limited. This study aims to analyze the compatibility of language proficiency descriptors in the Language Skills course curriculum of the
Muhammad Zaenuri, Sukirman, Umi Baroroh, Tulus Mustofa   +3 more
doaj   +1 more source

GENERAL LANGUAGE SKILLS INTEGRATION INTEGRATING THE FOUR LANGUAGE SKILLS IN COMMUNICATIVE LANGUAGE TEACHING

This article discusses the integration of the four primary language skills — listening, speaking, reading, and writing — within the framework of Communicative Language Teaching (CLT). It analyzes the interconnectedness of these skills in developing learners' communicative competence and explores effective methods for their integration during the ...
Turdimatova, Madinaxon, Mirzaxalilova, Shohsanambonu   +1 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Older adults’ perceptions about methodologies used to learn English as a foreign language

Cuadernos de Investigación Educativa
Older adults' increased longevity and improved health are becoming a great achievement in this century. In lifelong learning, active learners in the community benefit from a variety of courses offered by different institutions, with foreign language ...
Cecilia Cisterna Zenteno, Marcela Cabrera Abarza, Ignacio Roa Herrera   +2 more
doaj   +1 more source

Opportunities to develop language skills in Czech lower-secondary English classes: Separated or integrated approach? [PDF]

Pedagogická Orientace, 2011
Contemporary approach to foreign language education is based on the communicativeapproach and the communicative competence as its goal. The questionis, to what extent the goals are reflected in foreign language classes.
Simona Šebestová, Petr Najvar, Tomáš Janík   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source