Results 101 to 110 of about 4,484,521 (303)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

An LSP Framework for Translation and Interpreting Pedagogy

Revista de Lenguas para Fines Específicos, 2021
In this article, we present a pedagogical framework for foreign language teaching in undergraduate translation and interpreting programmes. Within Translation Studies, many scholars support the idea that TILLT (Translation- and Interpreting-oriented ...
Enrique Cerezo Herrero, Astrid Schmidhofer, Melita Koletnik   +2 more
doaj  

From 1970s until present: New horizons of cognitive linguistics and its application in CLIL, teaching languages and literature, SLA and translation studies [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2020
The present paper studies some important stages of evolution of cognitive linguistics from the 1970s till present. One of the main ideas, appeared in the second half of the last century, which lies at the basis of cognitive linguistics is that language ...
Boyarkina Iren
doaj  

English in contact with Pashto and other Pakistani languages: A review of studies on the language interplay

Social Sciences Spectrum
Languages in contact impact each other in multiple ways. Various studies have been conducted to report how the official and the regional languages in Pakistan affect each other. However, they are too scarce to cover the multitude of the languages and the multiplicity of ways in which they influence each other.
Dr. Intikhab Alam, Dr. Farrukh Kamran, Muhammad Kamal   +2 more
openaire   +1 more source

Language, Ethics, and the Other between Athens and Jerusalem: A Comparative Study of Plato and Rosenzweig [PDF]

Philosophy East and West, 1995
Speech, ethics and the other between Athens and Jerusalem A comparative study of Plato and Rosenzweig The starting hypothesis of this study consists in the insight that the way of speeking determines what kind of reality can be the object of language and what kind of relationality is possible.
openaire   +1 more source

Fearless Friday: Jasmine Santana

, 2015
In this week’s Fearless Friday piece, SURGE would like to spotlight Jasmine Santana ’16! Jasmine is a currently a senior IDS major who focuses on socio-linguistics. In other words, she critically analyzes the use of language through various perspectives,
Bassler, Christina L.
core  

How are English language teachers supported to develop professional knowledge and practice, within their schools? Qualitative Study [PDF]

, 2017
This was a small-scale, qualitative study into the experiences of ‘support in school for improving knowledge and practice of ELT’ amongst teachers participating in a large- scale, quantitative, quasi-experimental (QE) study (EIA, 2017).
Griffiths, Malcolm, Mathew, Rama, Power, Tom   +2 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source