Results 51 to 60 of about 1,037,636 (310)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda   +15 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Acehnese Language Use in South Aceh Regency: A Sociolinguistic Analysis

open access: yesBuletin Al-Turas
Purpose This study aimed to find out how the Acehnese language is used by residents in the South Aceh Regency. Method This research used a qualitative approach with documentary studies, meta-ethnographic research, field studies, focus group discussions
Zulkhairi Zulkhairi   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Computational Linguistics and Adaptation of Turkic Languages to Computer [PDF]

open access: yesUluslararası Uygur Araştırmaları Dergisi, 2017
This article describes computational linguistics briefly, and explains Turkic language studies in this field using Uyghur language as an example. With developing computer technologies, many software has been implemented in order to complete some tasks in
Murat Orhun
doaj  

Neuroimaging of voice hearing in non-psychotic individuals: A mini review of recent fMRI, PET, DTI and EEG studies

open access: yesFrontiers in Human Neuroscience, 2012
Auditory verbal hallucinations (AVH) or ‘voices’ are a characteristic symptom of schizophrenia, but can also be observed in healthy individuals in the general population.
Kelly Maria Johanna Diederen   +2 more
doaj   +1 more source

Use of Other Languages in English Language Teaching at Tertiary Level: A Case Study on Bangladesh

open access: yesEnglish Language Teaching, 2012
There has been a continuous debate over a long period over the issue of using the learner’s mother tongue in teaching the second language. We have two schools in this regard – monolingual approach and bilingual approach. Those advocating the monolingual approach have claimed that learning is determined by the quantity of exposure to the target language.
Md. Golam Hoshain Mirza   +2 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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