Results 71 to 80 of about 1,037,636 (310)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
A Contrastive Study of Resultative Constructions in Albanian and Other Languages
Journal of Educational and Social ResearchIn the last two or three decades, linguists have paid great attention to certain ways and means of expressing result, especially in English and other Germanic languages, but also in Neo-Latin and Slavic languages, as well as in Chinese, Japanese, Korean and the like.
Aida Kurani, Anisa Trifoni
openaire +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
An LSP Framework for Translation and Interpreting Pedagogy
Revista de Lenguas para Fines Específicos, 2021 In this article, we present a pedagogical framework for foreign language teaching in undergraduate translation and interpreting programmes. Within Translation Studies, many scholars support the idea that TILLT (Translation- and Interpreting-oriented ...
Enrique Cerezo Herrero +2 more
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Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
From 1970s until present: New horizons of cognitive linguistics and its application in CLIL, teaching languages and literature, SLA and translation studies [PDF]
Zbornik Radova Filozofskog Fakulteta u Prištini, 2020 The present paper studies some important stages of evolution of cognitive linguistics from the 1970s till present. One of the main ideas, appeared in the second half of the last century, which lies at the basis of cognitive linguistics is that language ...
Boyarkina Iren
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