Results 241 to 250 of about 1,077,888 (308)

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Understanding Dysphagia Care in Pakistan: A Survey of Current Speech Language Therapy Practice. [PDF]

Dysphagia
Akhtar RN, Behn N, Morgan S.
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Natural language acquisition and gestalt language processing: A critical analysis of their application to autism and speech language therapy. [PDF]

Autism Dev Lang Impair
Hutchins TL, Knox SE, Fletcher EC.
europepmc   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Clinical efficacy and therapeutic mechanism of active 'five-tone' speech therapy compared with conventional speech-language therapy for treatment of post-stroke aphasia: protocol for a randomised controlled trial. [PDF]

BMJ Open
Wang M, Ni J, Lin B, Huang J.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Exploring the valued outcomes of school-based speech-language therapy services: a sequential iterative design. [PDF]

Front Rehabil Sci
Cahill PT, Ng S, Turkstra LS, Ferro MA, Campbell WN.   +4 more
europepmc   +1 more source

Resting-state brain network connectivity is an independent predictor of responsiveness to language therapy in chronic post-stroke aphasia. [PDF]

Cortex
Falconer I, Varkanitsa M, Kiran S.
europepmc   +1 more source

Dubbing language-therapy CINEma-based in aphasia post-stroke (DULCINEA): A feasibility randomized crossover controlled trial. [PDF]

Digit Health
Fuentes B, Jordi-Perea P, Sempere-Iborra C, Tarifa-Rodríguez A, de Celis-Ruiz E, Martín Alonso M, Ruiz-Ares G, Rigual R, Rodríguez-Pardo J, Alonso-López E, Alonso de Leciñana M, Virués-Ortega J, Borobia AM, Jiménez-González M, Martínez-Balaguer M, Blanco P, Bueno N.   +16 more
europepmc   +1 more source