Results 81 to 90 of about 1,077,888 (308)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The effect of mild-stage Alzheimer’s disease on the acoustic parameters of voice

The Egyptian Journal of Otolaryngology
Objective Our study aimed to reveal the differences by comparing the objective and subjective voice features of individuals diagnosed with mild-stage Alzheimer’s disease (AD) with those with normal cognitive abilities.
Emel Arslan-Sarımehmetoğlu, Elife Barmak   +1 more
doaj   +1 more source

Evaluation of Auditory Evoked Potentials in Neuromyelitis Optica Spectrum Disorder

Journal of Integrative Neuroscience
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a recurrent demyelinating neuroinflammatory disorder of the central nervous system.
Lucas Pinto Mielle, Liliane Aparecida Fagundes Silva, Dayane Aparecida Nascimento Barbosa, Glauciene Amaral Martins, Alessandra Giannella Samelli, Carla Gentile Matas   +5 more
doaj   +1 more source

Speech and language therapy

Morecambe Bay Medical Journal, 1996
Speech and language therapy is primarily concerned with assessment, diagnosis and clinical management of communication difficulties, which can occur across a wide age range, and may be congenital, developmental or acquired. Some therapists are also qualified to work with certain types of swallowing difficulties.
openaire   +2 more sources

Communicative-Pragmatic Assessment Is Sensitive and Time-Effective in Measuring the Outcome of Aphasia Therapy [PDF]

, 2017
A range of methods in clinical research aim to assess treatment-induced progress in aphasia therapy. Here, we used a crossover randomized controlled design to compare the suitability of utterance-centered and dialogue-sensitive outcome measures in speech-
Andres, Austin, Benjamin Stahl, Berthier, Berthier, Bettina Mohr, Bhogal, Blomert, Brady, Bruner, Cherney, Difrancesco, Egorova, Egorova, Egorova, Faul, Felix R. Dreyer, Friedemann Pulvermüller, Glenberg, Goodglass, Guglielmo Lucchese, Holland, Horn, Huber, Kemmerer, Kertesz, Kessels, Lomas, Meinzer, Meinzer, Oldfield, Pulvermüller, Pulvermüller, Pulvermüller, Rorden, Searle, Stahl, Stahl, Szaflarski, Tomasello, Willems, Wittgenstein   +41 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Who really decides? Feeding decisions ‘made’ by caregivers of children with cerebral palsy

South African Journal of Communication Disorders
Background: There are no definitive guidelines for clinical decisions for children with cerebral palsy (CP) requiring enteral feeds. Traditionally, medical doctors made enteral feeding decisions, while patients were essentially treated passively within a
Lavanya Naidoo, Mershen Pillay, Urisha Naidoo   +2 more
doaj   +1 more source

The treatment of a severe ataxic dysarthria, using electropalatography. Single case study [PDF]

, 1997
Electropalatography has been used successfully with several client groups (Hardcastle et al 1991). Intelligibility has been improved in children with articulation difficulties as a result of cleft palate, or with dyspraxia, or long standing phonological ...
Kelly, Stephen W., Main, Alison, Manley, Graham   +2 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source