Results 51 to 60 of about 1,275,595 (301)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The Holistic Advantage: Unified Quantitative Modeling for Less-Biased, In-Depth Insights into (Socio)Linguistic Variation

open access: yesLanguages
What happens when recognized and diverse conditioning factors of linguistic variation are omitted from analysis and/or are not analyzed under a single analytical procedure? This paper explores the consequences of such a choice on data interpretation and,
Wilkinson Daniel Wong Gonzales
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

How to explain linguistic variation and its role in language change

open access: yesZeitschrift für Sprachwissenschaft
Linguistic variation is a feature that characterizes every natural language. In this paper, I focus on linguistic variation and its importance and its role in language change (LC).
Weiß Helmut
doaj   +1 more source

Competition of synonyms through time: Conceptual and social salience factors and their interrelations

open access: yesCatalan Journal of Linguistics, 2015
This paper highlights three theoretical and descriptive insights into synonymy and lexical variation and change: (1) the diachronic development of synonymous forms reveals essential aspects about the nature and motivations of synonymy; (2) the emergence ...
Augusto Soares da Silva
doaj   +1 more source

The speech community [PDF]

open access: yes, 2001
The speech community (SpCom), a core concept in empirical linguistics, is at the intersection of many principal problems in sociolinguistic theory and method.
Patrick, Peter L
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Inferring social meaning from language variation: liminality and gender [PDF]

open access: yes, 2019
The variationist sociolinguistic enterprise has long been interested in the systematicities of language variation. While tensions between internal (structural) and external (social) factors have been productively explored within the variationist ...
Hazenberg, Evan
core  

Toward a model of multiple paths to language learning: response to commentaries [PDF]

open access: yes, 2017
Language learning, while seemingly effortless for young learners, is a complex process involving many interacting pieces, both within the child and in their language-learning environments, which can result in unique language learning trajectories and ...
AUDREY DELCENSERIE   +8 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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