Results 221 to 230 of about 48,825,372 (259)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

ProtoSurv: prototype-guided adaptation of computed tomography foundation model for lung-cancer prognosis prediction. [PDF]

Vis Comput Ind Biomed Art
Liu C, Li S, Sang H, Huang X, Wang C, Shu Y, Wu Y, Tian J, Zhang H, Zhang L, Wang S.   +10 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Endovascular Treatment for Patients Aged ≥80 Years with Large Ischemic Stroke. [PDF]

Clin Interv Aging
Ding C, Li L, Li G, Liu Z, Zhang L, Zhu H, Xu X, Ma J, Feng K, Chen C, Song J, Zhou M, Zi W.   +12 more
europepmc   +1 more source

Large language models in bioinformatics: a comprehensive survey. [PDF]

Front Genet
Meng Z, Yang Z, Zhu M, Xu J.
europepmc   +1 more source

Development of the LARyNGTH score to predict central neurogenic respiratory failure in lateral medullary infarction. [PDF]

Front Neurol
Kim YS, Park SY, Park JH, Park B, Lee JS, Lee SJ.   +5 more
europepmc   +1 more source

Effectiveness of the Healthy Hearing Promoting Program (HHPP) among workers in large-scale industries: A randomized controlled trial in central Thailand. [PDF]

Belitung Nurs J
Kaewfong I, Kaewthummanukul T, Lirtmunlikaporn S, Wichaikhum OA.   +3 more
europepmc   +1 more source