Results 171 to 180 of about 11,102,357 (292)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Benchmarking Zero-Shot Open-Vocabulary and Fine-Tuned Object Detectors for Underground Mine Personnel Detection. [PDF]

Sensors (Basel)
Essien E, Frimpong S.
europepmc   +1 more source

Ultrathin 2D In2O3 Nanosheets Confining Cu Single Atoms Synergized With Oxygen Vacancies for High Selectivity of Photocatalytic Reduction of CO2 to CO

Advanced Science, EarlyView.
In this work, we constructed an ultrathin two‐dimensional (2D) In2O3 nanosheet (In2O3‐Ns) structure based on oxygen vacancies (OV)‐rich defects and low crystallinity to anchor Cu single atoms (Cu SAs) and synthesized Cu/In2O3‐Ns photocatalysts. ABSTRACT In this work, we constructed an ultrathin two‐dimensional (2D) In2O3 nanosheet (In2O3‐Ns) structure ...
Yueying Yang, Xuan Xiang, Jiali Ren, Ying Bian, Xinyu Wang, Xiaoyang Lu, Yanjun Xue, Porun Liu, Cheng‐Hao Chuang, Xiaoli Zhang, Jian Tian   +10 more
wiley   +1 more source

From sequence space to ecological function: microbiome-derived antimicrobial peptides as community effectors and therapeutic leads. [PDF]

Essays Biochem
Oyama LB.
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Lithium and Water: Why Hydrological Limits Will Define a Just Energy Transition. [PDF]

Glob Chall
Barra RO, Álvarez-Amado F, Parra V, Salgado M, Alvarez S, Alvez A, Gutiérrez L.   +6 more
europepmc   +1 more source

High‐Throughput Screening for Accelerated Oxide Glass Discovery

Advanced Science, EarlyView.
A high‐throughput screening platform is presented that allows for accelerating laboratory glass synthesis by a factor of 102, using multicomponent stereolithographic printing. Automatic sample evaluation is achieved via Raman spectroscopy and similarity analysis without any sample preparation.
Igor Seibel‐Geraschenko, Josef Slowik, Franziska Scheffler, Alexis Duval, N. M. Anoop Krishnan, Lothar Wondraczek   +5 more
wiley   +1 more source

Integrated Assessment of Heavy Metals in Mining-Affected Soils in China: Source Identification, Ecological Risks, and Sustainable Remediation. [PDF]

Toxics
Zhao Y, Hua J, Fan T, Zhou Y, Wang X, Zhang S, Li Q.   +6 more
europepmc   +1 more source

Autonomous Solar Metallurgy for High‐Purity Gold Recovery from Electronic Waste

Advanced Science, EarlyView.
Inspired by microbial strategies for metal uptake and biomineralization, defect‐rich copper sulfide (Cu31S16) functions as a solar metallurgical platform that unifies Au(III) capture, reduction, and self‐separation. The bioinspired design enables ultrafast gold recovery from electronic‐waste leachates and the spontaneous formation of millimeter‐scale ...
Chaopeng Liu, Jiajun Li, Jialin Ruan, Wei Zhang, Wei Sun, Hongmei Li, Lei Xie, Min Liu   +7 more
wiley   +1 more source

Evaluation of the high-quality development of graduate education in mining engineering based on ISM and Bayesian networks. [PDF]

PLoS One
Wu L, Sun Z, Yang Y.
europepmc   +1 more source