Results 51 to 60 of about 609,298 (293)

Quasi-steady quasi-homogeneous description of the scale interactions in near-wall turbulence

, 2016
By introducing a notion of an ideal large-scale filter, a formal statement is given of the hypothesis of the quasi-steady quasi-homogeneous nature of the interaction between the large and small scales in the near-wall part of turbulent flows.
Chernyshenko, SI, Zhang, C
core   +1 more source

A Homotopy Method for Large-Scale Multi-Objective Optimization

, 2015
A homotopy method for multi-objective optimization that produces uniformly sampled Pareto fronts by construction is presented. While the algorithm is general, of particular interest is application to simulation-based engineering optimization problems where economy of function evaluations, smoothness of result, and time-to-solution are critical.
Adelmann, Andreas, Arbenz, Peter, Foster, Andrew, Ineichen, Yves   +3 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Optimization of Discrete-parameter Multiprocessor Systems using a Novel Ergodic Interpolation Technique [PDF]

, 2015
Modern multi-core systems have a large number of design parameters, most of which are discrete-valued, and this number is likely to keep increasing as chip complexity rises. Further, the accurate evaluation of a potential design choice is computationally
Desai, Madhav P., Karanjkar, Neha V.
core  

Large scale multi-objective optimization: Theoretical and practical challenges

, 2016
Multi-objective optimization (MOO) is a well-studied problem for several important recommendation problems. While multiple approaches have been proposed, in this work, we focus on using constrained optimization formulations (e.g., quadratic and linear programs) to formulate and solve MOO problems.
Basu, Kinjal, Saha, Ankan, Chatterjee, Shaunak   +2 more
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Multiform-based evolutionary framework for large-scale constrained multi-objective optimization

Egyptian Informatics Journal
Large-scale constrained multi-objective optimization problems (LSCMOPs) are common in real-world scenarios. These multi-objective problems are characterized by high-dimensional decision spaces and complex constraints, posing a stiff challenge for ...
Shaojin Geng, Fei Ming, Dongyang Li, Weian Guo, Lei Wang, Qidi Wu   +5 more
doaj   +1 more source

Emergency logistics scheduling with multiple supply-demand points based on grey interval

Journal of Safety Science and Resilience, 2022
This study aimed to address the problem of post-disaster emergency material dispatching from multiple supply points to multiple demand points. In large-scale natural disasters, it is very important for multiple emergency material supply points to serve ...
Zhiming Ding, Xinrun Xu, Shan Jiang, Jin Yan, Yanbo Han   +4 more
doaj   +1 more source