Results 71 to 80 of about 5,819,297 (274)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A novel sliding mode control with MRAS inertia identification for permanent magnet synchronous motors

Measurement + Control
To enhance the anti-inertia disturbance ability of permanent magnet synchronous motor (PMSM) speed system, an adaptive sliding mode control with inertia identification is proposed.
Zhe Song, Xi Xiao, Jun Yang, Tao Tao, Xuesong Mei   +4 more
doaj   +1 more source

Large Scale CW ECRH Systems: Some considerations

EPJ Web of Conferences, 2012
Electron Cyclotron Resonance Heating (ECRH) is a key component in the heating arsenal for the next step fusion devices like W7-X and ITER. These devices are equipped with superconducting coils and are designed to operate steady state.
Turkin Y., Michel G., Marushchenko N. B., Lubiako L., Laqua H. P., Gantenbein G., Braune H., Petelin M.I., Lechte C., Plaum B., Kasparek W., Erckmann V., Weissgerber M.   +12 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Development of an Integrated Laser Sensors Based Measurement System for Large-Scale Components Automated Assembly Application

IEEE Access, 2018
In the field of precision docking or assembly of large scale, the orientation and position measurement system is quite demanding. This paper proposes a long-range measuring system with the combination of low-cost tilt sensor and laser sensors to achieve ...
Gaoliang Peng, Yu Sun, Shilong Xu
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

New Trends in Large Scale Distributed Systems Simulation

Journal of Algorithms & Computational Technology, 2011
In this paper we present recent developments in the domain of modeling and simulation of large scale distributed systems (LSDS). Such systems possess features that include resource sharing, openness, concurrency, scalability, fault-tolerance, and ...
Ciprian Dobre, Florin Pop, Valentin Cristea   +2 more
doaj   +1 more source

Engineering management of large scale systems [PDF]

The organization of high technology and engineering problem solving, has given rise to an emerging concept. Reasoning principles for integrating traditional engineering problem solving with system theory, management sciences, behavioral decision theory ...
Gill, Tepper L., Paul, Arthur S., Sanders, Serita   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source