Results 211 to 220 of about 727,226 (339)
Large deviations problems for random matrices
, 2017 Cette thèse s'inscrit dans le domaine des matrices aléatoires et des techniques de grandes déviations. On s'attachera dans un premier temps à donner des inégalités de déviations pour différentes fonctionnelles du spectre qui reflètent leurs comportement ...
Augeri, Fanny
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Large deviations in the Langevin dynamics of lattice disordered systems
, 2001 Michel Sortais
openalex +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Some remarks on large deviations for weighted sums if Cramér's condition is not satisfied [PDF]
, 1980 Werner Wolf
openalex +1 more source