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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

FEM Numerical Calculations and Experimental Verification of Extrusion Welding Process of 7075 Aluminium Alloy Tubes. [PDF]

Materials (Basel)
Leśniak D, Laber KB, Madura J.
europepmc   +1 more source

SemanticRail3D - A Mobile LiDAR Benchmark for Semantic and Instance Segmentation of Railway Corridors. [PDF]

Sci Data
Ghasemlou A, Soilán M, Riveiro B.
europepmc   +1 more source

Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy. [PDF]

Nat Commun
Xie K, Sahlas E, Ngo A, Chen J, Arafat T, Royer J, Zhou Y, Rodríguez-Cruces R, Dascal A, Caldairou B, Fadaie F, Barnett A, Audrain S, Larivière S, Caciagli L, Pana R, Weil AG, Grova C, Frauscher B, Schrader DV, Zhang Z, Concha L, Bernasconi A, Bernasconi N, Bernhardt BC.   +24 more
europepmc   +1 more source

Bayesian Cost-Effectiveness Analysis Using Individual-Level Data is Sensitive to the Choice of Uniform Priors on the Standard Deviations for Costs in Log-Normal Models. [PDF]

Pharmacoeconomics
Ling X, Gabrio A, Baio G.
europepmc   +1 more source

Detrended Cross-Correlations and Their Random Matrix Limit: An Example from the Cryptocurrency Market. [PDF]

Entropy (Basel)
Drożdż S, Jarosz P, Kwapień J, Skupień M, Wątorek M.   +4 more
europepmc   +1 more source

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On Large Deviations, II

Theory of Probability & Its Applications, 2000
The paper presents a new point of view on the Cramér type large deviations \[ P(\xi >x)=(1-\Phi (x))Q\exp(L) \] for the ``right tail'' of the distribution of a random variable \(\xi\). Here \(\Phi (x)\) is a standard normal distribution function, \(Q\) and \(L\) are some quantities depending on \(x\) and \(\xi\).
openaire   +2 more sources

Large deviations forU-statistics

Lithuanian Mathematical Journal, 1992
Let \(X_ 1, X_ 2, \dots\) be a sequence of independent random variables having common probability distribution \(F\), and let \(\varphi (x_ 1, \dots, x_ m)\) be a function (kernel) assumed (without loss of generality) to be symmetric in its arguments. For each such kernel we consider the associated \(U\)-statistic \[ U_ n={n \choose m}^{-1} \sum_{C_{nm}
openaire   +2 more sources