Results 181 to 190 of about 1,088,601 (319)

Large Deviation Theory Approach to Fluctuation Theorems and Landauer's Principle through Heat Redefinition [PDF]

Tatsuaki Tsuruyama
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

A theory of ecological invasions and its implications for eco-evolutionary dynamics. [PDF]

Proc Natl Acad Sci U S A
Feng Z, Blumenthal E, Mehta P, Goyal A.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Quantitative-genetic analysis of directional adaptation suggests low maximum sustainable rates of change in agreement with data from field populations. [PDF]

Sci Rep
Pagel M, Gardner JD, Meade A.
europepmc   +1 more source

Large deviation analysis of the CPD detection problem based on random tensor theory

, 2017
Remy Bayer, Philippe Laubatan
openalex   +2 more sources

Post-Born corrections to the one-point statistics of (CMB) lensing convergence obtained via large deviation theory

, 2020
Alexandre Barthelemy, Sandrine Codis, Francis Bernardeau   +2 more
openalex   +1 more source

Path large deviations for the kinetic theory of weak turbulence

, 2022
Jules Guioth, Freddy Bouchet, Gregory L. Eyink   +2 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Sparse identification of nonlinear dynamics applied to the acoustic levitation of acoustically large objects. [PDF]

Sci Rep
Akbarzadeh M, Halkon B, Oberst S.
europepmc   +1 more source