Results 161 to 170 of about 159,850 (300)

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Feeding the hospitalized large-for-gestational-age infant: Clinical dilemmas and the need for growth standards. [PDF]

Nutr Clin Pract
Cortez NR, Hull HR, Christifano DN, Carlson SE, Goday PS.   +4 more
europepmc   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

A polygenic growth score and risk for large for gestational age birth weight. [PDF]

J Endocr Soc
Aamir M, Feghali M, Yee L, Silver RM, Durnwald C, Steller JG, Haas D, Reddy U, Guerrero RF, Scifres CM.   +9 more
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Lipid metabolism-based machine learning models for predicting large for gestational age in non-diabetic pregnancies. [PDF]

Front Endocrinol (Lausanne)
Liu W, Xu Y, Mi C, Yan S.
europepmc   +1 more source

THE ROLE OF GESTATIONAL DIABETES MELLITUS AND PREGNANCY WEIGHT GAIN ON RISK OF LARGE FOR GESTATIONAL AGE INFANTS: A RETROSPECTIVE STUDY

, 2014
Background It is important to identify the most important determinants of excessive fetal growth in our population. In healthy women, excessive gestational weight gain is a risk factor for large for gestational age infants as well as other perinatal and ...
Kamath, Vidyashri, Menon , Janaki, Brijit   +2 more
core  

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Post-thaw embryo culture and the risk of large-for-gestational-age offspring: a retrospective cohort study. [PDF]

Reprod Health
Vilk Ayalon N, Omer Vilk N, Sompolinsky Y, Azulay R, Godin M, Bentov Y, Esh-Broder E, Adler Lazarovits C, Ketzinel-Gilad M, Hizkiyahu R, Hershko Klement A.   +10 more
europepmc   +1 more source

Born Large for Gestational Age: Bigger Is Not Always Better [PDF]

The Journal of Pediatrics, 2016
Valentina Chiavaroli, José G.B. Derraik, Paul L. Hofman, Wayne S. Cutfield   +3 more
openaire   +2 more sources