This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang +4 more
wiley +1 more source
Field-Based Feasibility Assessment of Sorghum, Maize and Soybean for the Phytomanagement of Heavy Metal-Contaminated Mining Soils in a Living Lab Platform. [PDF]
Ioniță MF, Dunca EC, Radu SM.
europepmc +1 more source
Computational Analysis of the Vibrational Response of Lunar Regolith Made of Nonspherical Grains
ABSTRACT Vibration‐based systems have shown that appropriately oriented and tuned mechanical oscillations can disrupt regolith interlocking and promote flow. Building on this evidence, the present study investigates vibration‐controlled granular discharge as a potential ISRU (In Situ Resource Utilization) strategy, with the aim of supporting ...
Lewis Traquair +4 more
wiley +1 more source
Characterization and dynamic evolution law of transverse fractures in the upper protected coal seam. [PDF]
Zhan K, Wang M, Ma Y.
europepmc +1 more source
Abstract In studies of subsurface hydrology, monitoring and imaging techniques are used to estimate the moisture content, or to track moisture or injected tracer movement. One applied imaging technique is electrical resistance tomography (ERT), in which measurements collected using electrodes placed on the ground surface or in boreholes are used to ...
Mikko Räsänen +3 more
wiley +1 more source
The deformation characteristics and the prefabricated crack pressure relief stability control of a small coal pillar roadway under stress superposition. [PDF]
Cheng S, Ma Z, Li Y, Zhang X.
europepmc +1 more source
Abstract The first edition of the Ordnance Survey's 1:2500 County Series is marked with treed areas, such as woodlands and orchards, and, remarkably, freestanding trees. Consequently, it is an unparalleled source of information on the distribution of trees across Britain in the mid‐late nineteenth century, when the maps were first surveyed. In order to
Toby Pillatt, William A. P. Smith
wiley +1 more source
Rock layer deformation analysis and mitigation at fault-crossing mining sites in RCRM operations. [PDF]
Dongshan Y +5 more
europepmc +1 more source
Abstract Debates abound regarding how to use land for nature recovery and environmental governance. Such decisions require an understanding of benefits and trade‐offs, and increasingly rely on vast quantities of data, delivered through digital technologies.
Lucy Jenner +3 more
wiley +1 more source
Mechanistic study and control of coal pillar deformation and failure in gob-side roadways with extra-thick seams and hard roof. [PDF]
Zhou J +8 more
europepmc +1 more source

