Results 61 to 70 of about 1,503,716 (266)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Computer program for parameter optimization [PDF]

, 1968
Flexible, large scale digital computer program was designed for the solution of a wide range of multivariable parameter optimization problems.
Glatt, C. R., Hague, D. S.
core   +1 more source

Self-optimization in Large Scale Assembly

Procedia Engineering, 2013
Proceedings of the 5th Manufacturing Engineering Society International Conference : Zaragoza 26-28 June 2013 / Martín, Juan José Aguilar and Fabra, José Antonio Yagüe and Domingo, Miguel Ángel Lope and Mazo, Jorge Santolaria and García, José Antonio Albajez 5th Manufacturing Engineering Society International Conference, MESIC 2013, Zaragoza, Spain, 26 ...
Schmitt, Robert H., Jatzkowski, Philipp, Janßen, Markus, Bertelsmeier, Felix   +3 more
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Stochastic Block Mirror Descent Methods for Nonsmooth and Stochastic Optimization [PDF]

, 2013
In this paper, we present a new stochastic algorithm, namely the stochastic block mirror descent (SBMD) method for solving large-scale nonsmooth and stochastic optimization problems. The basic idea of this algorithm is to incorporate the block-coordinate
Dang, Cong D., Lan, Guanghui
core  

Enhancing Cooperative Coevolution for Large Scale Optimization by Adaptively Constructing Surrogate Models

, 2018
It has been shown that cooperative coevolution (CC) can effectively deal with large scale optimization problems (LSOPs) through a divide-and-conquer strategy.
Chen, An, Liang, Yongsheng, Pang, Bei, Ren, Zhigang   +3 more
core   +1 more source

Multimodal Optimization Enhanced Cooperative Coevolution for Large-Scale Optimization

IEEE Transactions on Cybernetics, 2019
Cooperative coevolutionary (CC) algorithms decompose a problem into several subcomponents and optimize them separately. Such a divide-and-conquer strategy makes CC algorithms potentially well suited for large-scale optimization. However, decomposition may be inaccurate, resulting in a wrong division of the interacting decision variables into different ...
Xingguang Peng, Yaochu Jin, Handing Wang
openaire   +5 more sources