Results 51 to 60 of about 432,825 (243)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Extending the scope of models for large-scale structure formation in the Universe [PDF]

, 1999
We propose a phenomenological generalization of the models of large-scale structure formation in the Universe by gravitational instability in two ways: we include pressure forces to model multi-streaming, and noise to model fluctuations due to neglected ...
Buchert, Thomas, Dominguez, Alvaro, Perez-Mercader, Juan   +2 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Exploring the Signature of Assembly Bias and Modified Gravity Using Small-scale Clusterings of Galaxies

The Astrophysical Journal
We apply a halo velocity bias model, γ _f , within the Aemulus simulation suite for General Relativity to investigate its efficacy in identifying the signature of assembly bias and Modified Gravity (MG).
Yirong Wang, Zhongxu Zhai, Xiaohu Yang, Jeremy L. Tinker   +3 more
doaj   +1 more source

Cosmological Information in the Marked Power Spectrum of the Galaxy Field

The Astrophysical Journal, 2023
Marked power spectra are two-point statistics of a marked field obtained by weighting each location with a function that depends on the local density around that point. We consider marked power spectra of the galaxy field in redshift space that up-weight
Elena Massara, Francisco Villaescusa-Navarro, ChangHoon Hahn, Muntazir M. Abidi, Michael Eickenberg, Shirley Ho, Pablo Lemos, Azadeh Moradinezhad Dizgah, Bruno Régaldo-Saint Blancard   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Holographic principle and large scale structure in the universe

, 2011
A reasonable representation of large scale structure, in a closed universe so large it's nearly flat, can be developed by extending the holographic principle and assuming the bits of information describing the distribution of matter density in the ...
Mongan, T. R.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lagrangian Perturbation Theory for Biased Tracers: Significance of the Number Conservation

The Astrophysical Journal
The Lagrangian perturbation theory provides a simple yet powerful way of computing the nonlinear matter power spectrum, and it has been applied to biased tracers such as halos and galaxies.
Peter Espenshade, Jaiyul Yoo
doaj   +1 more source