Results 181 to 190 of about 219,084 (199)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications. [PDF]

Eng Comput
Luo C, Li K, Herschman AR, Sun M, Waisman H, Vedula V, Kysar JW, Kalfa D.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Clinical and Patient Comparison of AI and Expert Digital Smile Design: A Prospective Paired Study. [PDF]

Dent J (Basel)
Almohareb T, Abou-Bakr A, Hassanein FEA, Ahmed Y, Hamza M, Aboheikal M, Nagi N.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A study on design and multimodal evaluation of intuitive interfaces for complex information systems in manned/unmanned cooperation. [PDF]

Sci Rep
Qu J, Chen S, Dang S, Wang W, Jiao H.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Vortex-Based Cavitation Devices for Continuous Emulsification: Influence of the Device Design, Scale-Up, and Scale-Out. [PDF]

Ind Eng Chem Res
Gode A, Kourousis K, Ranade VV.
europepmc   +1 more source

Machine learning-driven design of engineered cilia enables hybrid operations in acoustic microrobots. [PDF]

Nat Commun
Ling Y, Lu Y, Rich J, Liu M, Xu X, Naquin T, Chen Y, Li S, Zhong R, Yang K, Zhao S, Wu Q, Jin K, Huang TJ.   +13 more
europepmc   +1 more source

Response to: "best practices when benchmarking CATCH for the design of genome enrichment probes". [PDF]

Bioinformatics
Alanko JN, Slizovskiy IB, Lokshtanov D, Gagie T, Noyes NR, Boucher C.   +5 more
europepmc   +1 more source