Results 71 to 80 of about 6,425,235 (253)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development

Scientific Reports
FMRFamide-like peptides (FLPs) are widely conserved in nematodes. Here, we conducted a molecular genetic study to confirm that the flp-11 gene regulates larval development in the free-living soil nematode model species Caenorhabditis elegans.
Riko Uegaki, Sho Maega, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Akira Shiraishi, Honoo Satake, Tsuyoshi Kawano   +7 more
doaj   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

Development time, mortality, and bioenergetic responses of larvae of the giant barnacle Austromegabalanus psittacus (Molina 1788) under controlled hatchery conditions of temperature and salinity

Aquaculture Reports
Barnacle production is a new aquaculture activity, that has developed to a semi-industrial level with extensive cultures in floating systems. However, the mass culture of larvae and juveniles under controlled hatchery conditions have not yet been ...
Mauricio O. Pineda, Boris A. López, Paulina Gebauer, Kurt Paschke   +3 more
doaj   +1 more source

Influence of temperature on the larval development of the edible crab Cancer pagurus [PDF]

, 2009
The influence of temperature on larval survival and development was studied in the edible crab, Cancer pagurus, from a population off the Island of Helgoland, North Sea.
Keller, Martina, Thatje, S., Heilmayer, O., Anger, Klaus, Weiss, Monika, Heilmayer, Olaf, Anger, K., Brey, T., Brey, Thomas, Weiss, M.   +9 more
core   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Corrigendum: Methodologies for patellid limpets’ aquaculture: From broodstock management to juveniles

Frontiers in Marine Science, 2022
Diego Castejón, Diego Castejón, Loreto García, José M. Cañizares, Mirko De Girolamo, Mirko De Girolamo, Carla Nunes, Carla Nunes, Eduardo Isidro, Eduardo Isidro, Gercende Courtois de Viçose, Natacha Nogueira, Natacha Nogueira, Carlos A. P. Andrade, Carlos A. P. Andrade   +14 more
doaj   +1 more source

Imaging fictive locomotor patterns in larval Drosophila [PDF]

, 2015
S.R.P. was supported by a Newton International Fellowship (Royal Society) and a Junior Fellowship (Janelia Research Campus, Howard Hughes Medical Institute). T.G.B. was supported by a Medical Research Council (UK) PhD grant. J.B. was supported by a Henry
Pulver, Stefan, Taylor, Adam, Bayley, Timothy, Michael Bate (70275), Bate, Michael, Berthold Hedwig (359009), Hedwig, Berthold, Stefan R Pulver (16281800), Berni, Jimena, Jimena Berni (7875149), Timothy G Bayley (16281803), Adam L Taylor (16281806), Pulver, Stefan; id_orcid   +12 more
core   +2 more sources

Herbivory‐Induced Stomatal Opening Triggers the Dispersal of an Invasive Insect Herbivore

Advanced Science, EarlyView.
The invasive leafminer Phthorimaea absoluta uniquely manipulates plant defenses by inducing stomatal opening in tomato. This response, mediated by the stomatal regulator IQM1, enhances the release of the repellent volatile benzaldehyde. This volatile triggers the dispersal of adult moths, facilitates colonization of new hosts, and leads to rapid ...
Limin Chen, Xiaowei Li, Yaru Wang, Farman Ullah, Shuxing Zhou, Lemeng Dong, Weizhong He, Harro J. Bouwmeester, Youming Hou, Ian T. Baldwin, Yaobin Lu   +10 more
wiley   +1 more source