Results 221 to 230 of about 34,076 (280)

BNIP3‐Dependent Mitophagy Non‐Autonomously Regulates Systemic Aging via NF‐κB Suppression in Drosophila

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
Muscle aging is characterized by alterations in mitochondrial morphology and structure, leading to the accumulation of reactive oxygen species (ROS). This increase in ROS activates Key/Relish‐mediated inflammatory pathways, resulting in the production of antimicrobial peptides (AMPs) that further accelerate aging.
Zhouyang Deng   +11 more
wiley   +1 more source

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma

open access: yesCancer Science, Volume 117, Issue 5, Page 1481-1496, May 2026.
The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...
Shigetaka Komura   +24 more
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, Volume 293, Issue 10, Page 2825-2844, May 2026.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

Chlorella Polysaccharide Extract Attenuates Skin Aging via MAPK Pathway Suppression: Implications for Cosmetic Dermatology

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Chlorella polysaccharide extract (CPE) is a natural compound with known antioxidant and immunomodulatory properties. This study investigated its anti‐aging potential and underlying mechanism, with a focus on dermatological relevance.
Minghui Zhang   +6 more
wiley   +1 more source

Pharmacokinetics, Optimal Dosages, and Withdrawal Time of Florfenicol in Cobia (Rachycentron canadum) After Oral Administration via Medicated Feed

open access: yesJournal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 343-351, May 2026.
ABSTRACT Antimicrobial drugs are commonly used for the treatment of bacterial diseases in cobia (Rachycentron canadum), but information regarding the rationale of their therapeutic use, such as pharmacokinetics (PK), optimal dosages, and withdrawal time (WDT) in this species is very rare.
Jou‐An Shih   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy