Results 51 to 60 of about 33,794 (267)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus [PDF]

, 2014
The aim of the present work was to determine the in vitro effect of T. vulgaris and O. vulgare essential oils against E. granulosus protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10 μg/mL. The
Denegri, Guillermo Maria, Eguaras, Martin Javier, Elissondo, María Celina, Gende, Liesel Brenda, Maggiore, Marina Alejandra, Pensel, Patricia Eugenia   +5 more
core   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

An affordable, quality-assured community-based system for high-resolution entomological surveillance of vector mosquitoes that reflects human malaria infection risk patterns. [PDF]

, 2012
: BACKGROUND: More sensitive and scalable entomological surveillance tools are required to monitor low levels of transmission that are increasingly common across the tropics, particularly where vector control has been successful.
A Bhattarai, A Moody, Alpha D Malishee, Athuman Muhili, B Greenwood, BL Sharp, BL Sharp, BM Bolker, BM Greenwood, CC Campbell, CK Murray, D Collett, Daniel Msellemu, DF Hoel, DJ Gubler, E Mathenge, F Mutuku, FM Mutuku, FO Okumu, G Giglioli, Gerry F Killeen, GF Killeen, GF Killeen, GF Killeen, GF Killeen, GF Killeen, GF Killeen, GF Killeen, GW Fegan, H Bugoro, H Townson, HB Tanowitz, HM Ferguson, I Dusfour, I Kleinschmidt, I Kleinschmidt, J Keiser, JA Najera, JA Najera, JA Odetoyinbo, JA Rozendaal, JA Scott, JG Breman, JI Shililu, JL San Martín, JM Cohen, JR Zucker, JT Griffin, K Clinton, K Walker, K Walker, L Roberts, M Sikulu, M Tanner, MA Malakooti, MA Sattler, ME Toledo, MJ Vanek, MN Bayoh, MR Reddy, MT Gillies, MT Gillies, MW Service, National Bureau of Statistics, Neil F Lobo, Nicodem J Govella, NJ Govella, NJ Govella, NJ Govella, NJ Govella, P Barbazan, P Bejon, P Gillet, P Winch, PI Trigg, PJ Obenauer, PM Nyarango, PP Chaki, PP Chaki, Prosper P Chaki, R Mundry, RC Smallegange, RC Smallegange, RGA Feachem, RT Bryan, S Dongus, S Dongus, S Dongus, S Majambere, Samson S Kiware, SB Ogoma, SI Hay, SJ Ceesay, SJ Moore, Stefan Dongus, T Bousema, Tanya L Russell, TL Russell, TL Russell, TR Burkot, U Fillinger, U Fillinger, U Fillinger, U Fillinger, U Kitron, U Krockel, UR Bernier, V D'Acremont, WHO, World Urbanization Prospects, WP O'Meara, WP O'Meara, WR Mukabana, Y Geissbuhler, Y Geissbühler, Yeromin Mlacha, Ying Zhou, YT Qiu, Zacharia J Mtema   +118 more
core   +7 more sources

A giant renal hydatid cyst with pleural extension and epiploic localization management: A case report

Urology Case Reports, 2022
Hydatidosis is a rare parasitic disease that is endemic in many countries of the Mediterranean basin caused by the larval form of Echinococcus Granulosus. Among unusual localizations, renal involvement is rare, especially extension to the pleural cavity.
Mohamed Trigui, Karim Ayed, Wissem Triki, Imed Abbassi, Oussema Baraket, Samy Bouchoucha   +5 more
doaj   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

Cystic pulmonary hydatidosis

Lung India, 2016
Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by the larval stages of the cestode Echinococcus granulosus. Worldwide, pulmonary hydatid cyst is a significant problem medically, socially, and economically.
Malay Sarkar, Rajnish Pathania, Anupam Jhobta, Babu Ram Thakur, Rajesh Chopra   +4 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

The effectiveness of faecal removal methods of pasture management to control the cyathostomin burden of donkeys [PDF]

, 2014
Background: The level of anthelmintic resistance within some cyathostomin parasite populations has increased to the level where sole reliance on anthelmintic-based control protocols is not possible.
Burden, Faith A, Corbett, Christopher J., Denwood, Matthew J., Love, Sandy, Matthews, Jacqui B., Moore, Anna   +5 more
core   +2 more sources