Results 71 to 80 of about 249,351 (339)

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, EarlyView.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Efficacy of EMG/bioimpedance-triggered functional electrical stimulation on swallowing performance

European Journal of Translational Myology, 2016
In order to support swallowing, the efficacy of functional electrical stimulation for different stimulation settings of the submental musculature has been investigated.
Corinna Schultheiss, Thomas Schauer, Holger Nahrstaedt, Rainer O. Seidl, Jehoschua Bieler   +4 more
doaj   +1 more source

Standard or individualized quality of life for larynx cancer patients? [PDF]

Journal of Clinical and Investigative Surgery, 2018
Locally advanced larynx cancer benefits from curative surgery therapy. Clinical trials have been proposed for assessing the quality of life for patients with larynx malignant neoplasia who underwent radical surgery.
Roxana Ionescu, Serban V. Bertesteanu, Radu C. Popescu, Cristian Balalau, Razvan V. Scaunasu, Bogdan Popescu   +5 more
doaj   +1 more source

Perceived vocal morbidity in a problem asthma clinic [PDF]

, 2009
<p>Aims: Asthma treatment has the potential to affect patients' voices. We undertook detailed characterisation of voice morbidity in patients attending a problem asthma clinic, and we determined how patients' perceptions related to objective ...
A E Stanton, A McConnachie, Altman, Barnes, C E Bucknall, C Sellars, De Bodt, Dejonckere, Fairbanks, K MacKenzie, Stanton, Stanton, Stanton, Williamson   +13 more
core   +1 more source

SERS‐AI‐LUA‐Driven Salivary Diagnosis of Head and Neck Cancer Using Graphene‐Assisted Plasmonic Nanocorals

Advanced Science, EarlyView.
The developed graphene‐assisted plasmonic nanocoral platform enables sensitive, label‐free surface‐enhanced Raman scattering analysis of salivary metabolites for head and neck cancer (HNC) detection. When combined with machine learning classification and nonnegative least squares‐based spectral deconvolution, this approach achieves 98% diagnostic ...
Hyo Jeong Seo, Boyou Heo, Jun‐Yeong Yang, Rowoon Park, Sung‐Gyu Park, Jiyoung Yeo, So Hee Park, Chan Kwon Jung, Min‐Young Lee, Jooin Bang, Jun‐Ook Park, Ho Sang Jung   +11 more
wiley   +1 more source

Intelligent Sensing: The Emerging Integration of Machine Learning and Soft Sensors Based on Hydrogels and Ionogels

Advanced Science, EarlyView.
By integrating with machine learning (ML), hydrogel‐ and ionogel‐based soft sensors are gaining human brain‐like capabilities to perceive, learn, and predict. This review summarizes their advances, focusing on ML‐powered applications such as handwriting/gesture/object/motion/speech recognition, health monitoring, food detection, and beyond.
Wenqing He, Rumin Lin, Suixiu Kong, Mengyi Qiang, Lingqi Huang, Bing Dai, Xi Yao, Lei Su, Xueji Zhang   +8 more
wiley   +1 more source

Impact of Circular Stapler Size on Short‐Term Outcomes and Long‐Term Quality of Life After McKeown Esophagectomy

Annals of Gastroenterological Surgery, EarlyView.
In this study, we investigated the impact of circular stapler size on both short‐term outcomes and long‐term QOL after McKeown esophagectomy. We revealed that short‐term outcomes, including anastomotic leakage and stenosis, did not differ between patients who underwent anastomosis with a 21 mm stapler and those with a 23 mm stapler.
Suguru Maruyama, Katsutoshi Shoda, Yoshihiko Kawaguchi, Ryo Saito, Wataru Izumo, Kensuke Shiraishi, Shinji Furuya, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa   +9 more
wiley   +1 more source

Control of echolocation pulses by neurons of the nucleus ambiguus in the rufous horseshoe bat, Rhinolophus rouxi [PDF]

, 1986
1. Horseradish peroxidase was applied by iontophoretic injections to physiologically identified regions of the laryngeal motor nucleus, the nucleus ambiguus in the CF/FM batRhinolophus rouxi. 2.
Rübsamen, R., Schweizer, Hermann
core   +1 more source

Minimally Invasive Esophagectomy for Esophageal Cancer: Current Evidence and Future Perspectives

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Esophageal cancer is a highly aggressive malignancy with regional variations in histological subtypes. Adenocarcinoma predominates in Western countries, whereas squamous cell carcinoma is more common in Asia. Despite advances in multimodal therapy, esophagectomy remains the cornerstone of curative treatment, and the development of various ...
Hirotaka Konishi, Hiroyuki Inoue, Hitoshi Fujiwara, Atsushi Shiozaki   +3 more
wiley   +1 more source